Outcomes of matched sibling and alternative donor stem cell transplantation for 26 children with severe aplastic anemia

Ming Yun Hsieh, Tzeon Jye Chiou, Giun Yi Hung, Hsiu Ju Yen

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8 引文 斯高帕斯(Scopus)

摘要

In this study, we reported the outcomes of hematopoietic stem cell transplantation (HSCT) as a treatment modality for pediatric patients admitted over the past 20 years in a single institute. From January 1989 to January 2007, 26 patients with a median age of 8 years underwent 14 matched sibling donor (MSD) and 12 alternative donor (AD) transplantations. Two patients received second transplantation successfully after primary graft failure and late graft rejection. Two patients who received transplantation from matched unrelated donors (MUD) died of sepsis, and one of them also had a graft failure at death. The overall 5-year survival rate was 92.1%: 83.3% for AD transplantation and 100% for MSD transplantation. Grade II acute graft versus host disease (GVHD) developed in 3 patients, and extensive chronic GVHD developed in 2 patients. An interval of more than 6 months from diagnosis to transplantation was the major poor prognostic factor for our patients' survival. Thus, in our experience, HSCT from a MSD remains the first choice of treatment for pediatric patients with severe aplastic anemia. For patients without MSD, transplantation from an AD can also result in long-term survival. Earlier transplantation after diagnosis can also result in better outcomes.

原文英語
頁(從 - 到)54-60
頁數7
期刊International Journal of Hematology
91
發行號1
DOIs
出版狀態已發佈 - 1月 2010
對外發佈

ASJC Scopus subject areas

  • 血液學

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