Outcomes Following Discontinuation of E. coli l-Asparaginase Upon Severe Allergic Reactions in Children With Acute Lymphoblastic Leukemia

Hsiu Ju Yen, Wan Hui Chang, Hsi Che Liu, Ting Chi Yeh, Giun Yi Hung, Kang Hsi Wu, Ching Tien Peng, Yu Hsiang Chang, Te Kao Chang, Chih Cheng Hsiao, Jiunn Ming Sheen, Yu Hua Chao, Tai Tsung Chang, Shyh Shin Chiou, Pei Chin Lin, Shih Chung Wang, Ming Tsan Lin, Wan Ling Ho, Yu Chieh Chen, Der Cherng Liang

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background: Discontinuation of E. coli l-asparaginase in patients with acute lymphoblastic leukemia (ALL) is unavoidable upon severe allergic reaction. We sought to examine outcomes following E. coli l-asparaginase discontinuation due to severe allergic reactions. Procedure: We evaluated the outcome of children enrolled in Taiwan Pediatric Oncology Group-2002-ALL protocol between 2002 and 2012, who had E. coli l-asparaginase discontinued due to severe allergic reactions, and compared the outcomes of those who continued with Erwinia l-asparaginase (Erwinase) with those who did not. Results: Among 700 patients enrolled in this study, 33 patients had E. coli l-asparaginase treatment discontinued due to severe allergic reactions. Five-year overall survival did not differ significantly among the 648 patients without discontinuation (81 ± 1.6%, mean ± SE), compared to 17 patients with allergic reactions and treated with Erwinase (88 ± 7.8%) and 16 patients with allergic reactions but not treated with Erwinase (87 ± 8.6%). Among 16 patients who did not receive Erwinase, all 10 who received ≥50% of the scheduled doses of E. coli l-asparaginase before discontinuation survived without events. Conclusions: Erwinase treatment may not be needed for some ALL patients with severe allergy to E. coli l-asparaginase if ≥50% of prescribed doses were received and/or therapy is augmented with other agents.

原文英語
頁(從 - 到)665-670
頁數6
期刊Pediatric Blood and Cancer
63
發行號4
DOIs
出版狀態已發佈 - 4月 1 2016
對外發佈

ASJC Scopus subject areas

  • 兒科、圍產兒和兒童健康
  • 血液學
  • 腫瘤科

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