Outcome of patients with recurrent adult-type granulosa cell tumors - A Taiwanese Gynecologic Oncology Group study

Peng Hui Wang, Hsu Dong Sun, Hao Lin, Kung Liahng Wang, Wen Shiung Liou, Yao Ching Hung, Ying Cheng Chiang, Chien Hsing Lu, Hung Cheng Lai, Ting Chang Chang, Ming Shyen Yen, Chi An Chen, Chyong Hyeu Lai, Mu Shyen Yu, Cheng Yang Chou, Chi Lun Chang, Kuo Feng Huang, Chih Ming Ho, Tan Yuan Chu, Po Hui WangFu Shing Liu, Yuen Yee Kan, Ching Hu Wu

研究成果: 雜誌貢獻文章同行評審

8 引文 斯高帕斯(Scopus)

摘要

Objective: The aim of this study is to evaluate the long-term outcome of ovarian recurrent granulosa cell tumors (GCTs) in a large series of patients treated in Taiwanese Gynecologic Oncology Group (TGOG) centers and to define the prognostic parameters for survival. Materials and methods: A retrospective multi-institutional review of patients with recurrent ovarian GCTs treated in TGOG centers was conducted. The clinical and pathological characteristics, treatment, and outcomes of patients with ovarian recurrent GCTs were analyzed using Kaplan-Meier and Cox proportional hazards analyses to determine the predictors for survival. Results: A total of 44 patients from 16 medical centers were identified between January 1994 and December 2010. The median disease-free survival (DFS), postrecurrence survival, and overall survival (OS) were 61.5 months (range, 3.7-219.3 months), 55.8 months (range, 4.6-193.7 months), and 115.3 months (range, 17.2-390.6 months), respectively. In multivariate analysis, DFS (> 61.5 months versus ≤ 61.5 months, hazard ratio (HR) 0.15, 95% confidence interval (CI) 0.03-0.78, p = 0.024) at the initial operation after diagnosis of relapse was the only predictor that correlated with OS. Conclusion: DFS after the initial operation was the only important predictor for overall survival in patients with recurrent GCTs, regardless of treatment, suggesting that the natural behavior of the tumor is a critical factor for patients with recurrent GCTs.

原文英語
頁(從 - 到)253-259
頁數7
期刊Taiwanese Journal of Obstetrics and Gynecology
54
發行號3
DOIs
出版狀態已發佈 - 2015

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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