Outcome of patients with bulky IB (≥ 6 cm) cervical squamous cell carcinoma with and without cisplatin-based neoadjuvant chemotherapy

Peng Hui Wang, Yen Hou Chang, Ying Hui Yang, Wen Hsun Chang, Shu Yun Huang, Chiung Ru Lai, Chi Mou Juang, Yi Jen Chen, Huann Cheng Horng, Kuo Chang Wen, Heung Tat Ng, Chiou Chung Yuan, Kuan Chong Chao, Ming Shyen Yen

研究成果: 雜誌貢獻文章

11 引文 斯高帕斯(Scopus)

摘要

Objective: To study the surgical morbidity and outcomes of patients with markedly bulky cervical squamous cell carcinoma (≥ 6cm Cx-SCC) who underwent radical hysterectomy (RH) with and without neoadjuvant chemotherapy (NACT). Materials and methods: This retrospective study enrolled patients with International Federation of Gynecology and Obstetrics (FIGO) IB markedly bulky Cx-SCC who were treated with either three courses of weekly single agent cisplatin NACT (50mg/m2) and subsequent radical hysterectomy (NACT-RH) or direct radical hysterectomy (RH) between 1996 and 2001. A total of 60 patients fulfilled the criteria, including 35 and 25 patients with NsACT-RH and RH, respectively. Results: There was no statistically significant difference in basic characteristics between the two groups, except the smaller pathological tumor size, less blood loss, and lower immediate complication rate in the NACT-RH group. Median survival was 143.8months in the NACT-RH group and 129.8months in the RH group, respectively, without a statistically significant difference. Multivariate analysis showed that large pathological tumor size [hazard ratio (HR) 10.66, 95% confidence interval (CI) 2.93-38.80], the presence of para-aortic lymph node metastases and an immediate complication (HR 8.33 and 4.55, 95% CI 1.66-41.75 and 1.35-15.27, respectively) contributed to a worse outcome. Conclusion: Weekly single agent cisplatin NACT indeed reduced the pathological tumor size and immediate complication rate during the RH, supporting the feasibility of subsequent RH in the management of patients with bulky Cx-SCC.
原文英語
頁(從 - 到)330-336
頁數7
期刊Taiwanese Journal of Obstetrics and Gynecology
53
發行號3
DOIs
出版狀態已發佈 - 九月 1 2014

    指紋

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Medicine(all)

引用此

Wang, P. H., Chang, Y. H., Yang, Y. H., Chang, W. H., Huang, S. Y., Lai, C. R., Juang, C. M., Chen, Y. J., Horng, H. C., Wen, K. C., Ng, H. T., Yuan, C. C., Chao, K. C., & Yen, M. S. (2014). Outcome of patients with bulky IB (≥ 6 cm) cervical squamous cell carcinoma with and without cisplatin-based neoadjuvant chemotherapy. Taiwanese Journal of Obstetrics and Gynecology, 53(3), 330-336. https://doi.org/10.1016/j.tjog.2014.05.001