Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan

Wen Cheng Chao, Yi Wen Huang, Ming Chih Yu, Wen Ta Yang, Chou Jui Lin, Jen Jyh Lee, Ruay Ming Huang, Chi Chang Shieh, Shun Tien Chien, Jung Yien Chien

研究成果: 雜誌貢獻文章

3 引文 (Scopus)

摘要

The appearance of smear-positivity but culture-negativity (SPCN) for acid-fast bacilli among sputum specimen is frequently found in pulmonary tuberculosis (TB) patients during treatment. This study aimed to investigate clinical risk factors, impacts on treatment course, and relapse pattern associated with sputum SPCN. Methods: We retrospectively enrolled 800 patients with culture-proven pulmonary TB who were receiving standard treatment and follow-up at six TB-referral hospitals in Taiwan between January 2006 and December 2007. Relevant patient characteristics and chemotherapy data were analyzed for associations with incidence of SPCN. Data from patients who relapsed within 3 years after completing treatment were analyzed for associations with SPCN during treatment. Results: Of the 800 subjects, 111 (13.8%) had sputum SPCN during treatment. Three factors were found to predict the development of SPCN; namely, high initial acid-fast staining grading (OR, 3.407; 95% CI, 2.090-5.553), cavitation on chest-X ray films (OR, 2.217; 95% CI, 1.359-3.615), and smoking (OR, 1.609; 95% CI, 1.006-2.841). Patients with SPCN had longer treatment duration (rifampicin: 284 ± 91 vs. 235 ± 69 days,

原文英語
文章編號67
期刊BMC Infectious Diseases
15
發行號1
DOIs
出版狀態已發佈 - 二月 18 2015

指紋

Taiwan
Tuberculosis
Sputum
Pulmonary Tuberculosis
Therapeutics
Chronic Disease Hospitals
X-Ray Film
Acids
Rifampin
Bacillus
Thorax
Referral and Consultation
Smoking
Staining and Labeling
Recurrence
Drug Therapy
Incidence

ASJC Scopus subject areas

  • Infectious Diseases

引用此文

Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan. / Chao, Wen Cheng; Huang, Yi Wen; Yu, Ming Chih; Yang, Wen Ta; Lin, Chou Jui; Lee, Jen Jyh; Huang, Ruay Ming; Shieh, Chi Chang; Chien, Shun Tien; Chien, Jung Yien.

於: BMC Infectious Diseases, 卷 15, 編號 1, 67, 18.02.2015.

研究成果: 雜誌貢獻文章

Chao, WC, Huang, YW, Yu, MC, Yang, WT, Lin, CJ, Lee, JJ, Huang, RM, Shieh, CC, Chien, ST & Chien, JY 2015, 'Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan', BMC Infectious Diseases, 卷 15, 編號 1, 67. https://doi.org/10.1186/s12879-015-0795-1
Chao, Wen Cheng ; Huang, Yi Wen ; Yu, Ming Chih ; Yang, Wen Ta ; Lin, Chou Jui ; Lee, Jen Jyh ; Huang, Ruay Ming ; Shieh, Chi Chang ; Chien, Shun Tien ; Chien, Jung Yien. / Outcome correlation of smear-positivity but culture-negativity during standard anti-tuberculosis treatment in Taiwan. 於: BMC Infectious Diseases. 2015 ; 卷 15, 編號 1.
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abstract = "The appearance of smear-positivity but culture-negativity (SPCN) for acid-fast bacilli among sputum specimen is frequently found in pulmonary tuberculosis (TB) patients during treatment. This study aimed to investigate clinical risk factors, impacts on treatment course, and relapse pattern associated with sputum SPCN. Methods: We retrospectively enrolled 800 patients with culture-proven pulmonary TB who were receiving standard treatment and follow-up at six TB-referral hospitals in Taiwan between January 2006 and December 2007. Relevant patient characteristics and chemotherapy data were analyzed for associations with incidence of SPCN. Data from patients who relapsed within 3 years after completing treatment were analyzed for associations with SPCN during treatment. Results: Of the 800 subjects, 111 (13.8{\%}) had sputum SPCN during treatment. Three factors were found to predict the development of SPCN; namely, high initial acid-fast staining grading (OR, 3.407; 95{\%} CI, 2.090-5.553), cavitation on chest-X ray films (OR, 2.217; 95{\%} CI, 1.359-3.615), and smoking (OR, 1.609; 95{\%} CI, 1.006-2.841). Patients with SPCN had longer treatment duration (rifampicin: 284 ± 91 vs. 235 ± 69 days,",
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