Oseto tissue regeneration on Poly-ε-caprolactone with biomedical ceramic materials

Ming Jyh Chern, Yung Kang Shen, Jia Hsiang Hung

研究成果: 雜誌貢獻文章同行評審

1 引文 斯高帕斯(Scopus)

摘要

3D porous biodegradable polymer scaffolds have been used for tissue engineering of bone repair or regeneration. The primary function of scaffolds is to provide structure support for the cells adhesion and proliferation. This study uses the Poly-ε-caprolactone (PCL) as material, NaCl mixed with hydroxyapatite (HA). This study uses the solution casting/particulate leaching method to fabricate the porous scaffold. This study discusses the compression mechanical properties, physical properties (porosity, moisture content, contact angle) of a pure PCL, PCL/mHA and PCL/nHA scaffolds. The in vitro cell culture is used for osteoblast cell (MG63) and the microculture tetrazolium test (MTT) is undertaken in the scaffold. The scaffolds are implanted to the femur of rats and histological examination is attempted after 2 weeks. The experimental results indicate that HA can improve the hydrophilic property. In conclusion, the PCL/nHA scaffold exhibits splendid in vivo biocompatibility and osteogenesis.
原文英語
頁(從 - 到)2572-2575
頁數4
期刊Advanced Science Letters
19
發行號9
DOIs
出版狀態已發佈 - 九月 2013

ASJC Scopus subject areas

  • 教育
  • 健康(社會科學)
  • 數學(全部)
  • 能源(全部)
  • 電腦科學(全部)
  • 環境科學 (全部)
  • 工程 (全部)

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