摘要
We previously reported our characterizations of the B-lymphoma tumors induced in a highly susceptible line of chickens (15I5 x 72) by the avian leukosis virus RAV-1 (Proc. Natl. Acad. Sci. 78:3418-3422, 1981). We demonstrated that in >90% of the tumors, the RAV-1 provirus is integrated near a cellular oncogene, c-myc. In the present study, we devised a simple approach, relying on SalI digestion, for further defining the locations and orientations of the proviruses with respect to the c-myc gene. We report here that in the great majority of cases the provirus is situated upstream from and in the same transcriptional direction as the c-myc gene - a configuration compatible with the promoter-insertion model proposed by Hayward et al. (Nature [London] 290:475-480, 1981).
原文 | 英語 |
---|---|
頁(從 - 到) | 742-746 |
頁數 | 5 |
期刊 | Journal of Virology |
卷 | 44 |
發行號 | 2 |
DOIs | |
出版狀態 | 已發佈 - 12月 1 1982 |
對外發佈 | 是 |
ASJC Scopus subject areas
- 免疫學