Organ biodistribution, clearance, and genotoxicity of orally administered zinc oxide nanoparticles in mice

Ching Hao Li, Chuan Chou Shen, Yu Wen Cheng, Shih Hsuan Huang, Chung Che Wu, Chen Chieh Kao, Jiunn Wang Liao, Jaw Jou Kang

研究成果: 雜誌貢獻文章同行評審

156 引文 斯高帕斯(Scopus)

摘要

Understanding tissue biodistribution and clearance of zinc oxide nanoparticles (ZnO-NPs) is necessary for its risk assessment. Both fed and intraperitoneally injected ZnO-NPs (2.5 g/kg) were absorbed into circulation (within 30 min post-dosing), then biodistributed to the liver, spleen, and kidney. Intraperitoneally injected ZnO-NPs remained in serum for 72 h and could more effectively spread to the heart, lung, and testes, whereas the clearance for fed ZnO-NPs in serum began 6 h after oral administration. Compared with zinc oxide microparticles (ZnO-MPs), ZnO-NPs exhibited much higher absorptivity and tissue biodistribution in fed treatment. A greater fraction of fed ZnO-NPs localised in the liver resulted in transient histopathological lesions. However, superoxide generation and cytotoxicity were showed in vitro treatment with ZnO-NPs (above 20 μg/mL). Considering both in vitro and in vivo data, the ZnO-NPs induced acute liver toxicity which was in compliance with its absorption, biodistribution, and clearance.
原文英語
頁(從 - 到)746-756
頁數11
期刊Nanotoxicology
6
發行號7
DOIs
出版狀態已發佈 - 十一月 2012

ASJC Scopus subject areas

  • Biomedical Engineering
  • Toxicology

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