Orexins: A role in medullary sympathetic outflow

Nae J. Dun, Siok Le Dun,, Chiung Tong Chen, Ling Ling Hwang, Ernest H. Kwok, Jaw Kang Chang

研究成果: 雜誌貢獻回顧型文獻

73 引文 (Scopus)

摘要

Orexin A and B, also known as hypocretin 1 and 2, are two recently isolated hypothalamic peptides. As orexin-containing neurons are strategically located in the lateral hypothalamus, which has long been suspected to play an important role in feeding behaviors, initial studies were focused on the involvement of orexins in positive food intake and energy metabolism. Recent studies implicate a more diverse biological role of orexins, which can be manifested at different level of the neuraxis. For example, canine narcolepsy, a disorder with close phenotypic similarity to human narcolepsy, is caused by a mutation of hypocretin receptor 2 gene. Results from our immunohistochemical and functional studies, which will be summarized here, suggest that the peptide acting on neurons in the rostral ventrolateral medulla augment sympathoexcitatory outflow to the spinal cord. This finding is discussed in the context of increased sympathetic activity frequently associated with obesity. Copyright (C) 2000 Elsevier Science B.V.
原文英語
頁(從 - 到)65-70
頁數6
期刊Regulatory Peptides
96
發行號1-2
DOIs
出版狀態已發佈 - 十二月 22 2000
對外發佈Yes

指紋

Narcolepsy
Neurons
Orexin Receptors
Lateral Hypothalamic Area
Peptides
Feeding Behavior
Energy Metabolism
Orexins
Canidae
Spinal Cord
Obesity
Eating
Genes
Mutation

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

引用此文

Dun, N. J., Le Dun, S., Chen, C. T., Hwang, L. L., Kwok, E. H., & Chang, J. K. (2000). Orexins: A role in medullary sympathetic outflow. Regulatory Peptides, 96(1-2), 65-70. https://doi.org/10.1016/S0167-0115(00)00202-0

Orexins : A role in medullary sympathetic outflow. / Dun, Nae J.; Le Dun, Siok; Chen, Chiung Tong; Hwang, Ling Ling; Kwok, Ernest H.; Chang, Jaw Kang.

於: Regulatory Peptides, 卷 96, 編號 1-2, 22.12.2000, p. 65-70.

研究成果: 雜誌貢獻回顧型文獻

Dun, NJ, Le Dun, S, Chen, CT, Hwang, LL, Kwok, EH & Chang, JK 2000, 'Orexins: A role in medullary sympathetic outflow', Regulatory Peptides, 卷 96, 編號 1-2, 頁 65-70. https://doi.org/10.1016/S0167-0115(00)00202-0
Dun, Nae J. ; Le Dun, Siok ; Chen, Chiung Tong ; Hwang, Ling Ling ; Kwok, Ernest H. ; Chang, Jaw Kang. / Orexins : A role in medullary sympathetic outflow. 於: Regulatory Peptides. 2000 ; 卷 96, 編號 1-2. 頁 65-70.
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AU - Kwok, Ernest H.

AU - Chang, Jaw Kang

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N2 - Orexin A and B, also known as hypocretin 1 and 2, are two recently isolated hypothalamic peptides. As orexin-containing neurons are strategically located in the lateral hypothalamus, which has long been suspected to play an important role in feeding behaviors, initial studies were focused on the involvement of orexins in positive food intake and energy metabolism. Recent studies implicate a more diverse biological role of orexins, which can be manifested at different level of the neuraxis. For example, canine narcolepsy, a disorder with close phenotypic similarity to human narcolepsy, is caused by a mutation of hypocretin receptor 2 gene. Results from our immunohistochemical and functional studies, which will be summarized here, suggest that the peptide acting on neurons in the rostral ventrolateral medulla augment sympathoexcitatory outflow to the spinal cord. This finding is discussed in the context of increased sympathetic activity frequently associated with obesity. Copyright (C) 2000 Elsevier Science B.V.

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