Orbitofrontal cortical dysfunction in akinetic catatonia: A functional magnetic resonance imaging study during negative emotional stimulation

Georg Northoff, Rolf Kötter, Frank Baumgart, Peter Danos, Heinz Boeker, Thomas Kaulisch, Florian Schlagenhauf, Henrik Walter, Alexander Heinzel, Thómas Witzel, Bernhard Bogerts

研究成果: 雜誌貢獻文章同行評審

100 引文 斯高帕斯(Scopus)

摘要

Catatonia is a psychomotor syndrome characterized by concurrent emotional, behavioral, and motor anomalies. Pathophysiological mechanisms of psychomotor disturbances may be related to abnormal emotional-motor processing in prefrontal cortical networks. We therefore investigated prefrontal cortical activation and connectivity patterns during emotional-motor stimulation using functional magnetic resonance imaging (FMRI). We investigated 10 akinetic catatonic patients in a postacute state and compared them with 10 noncatatonic postacute psychiatric controls (age-, sex-, diagnosis-, and medication-matched) and 10 healthy controls. Positive and negative pictures from the International Affective Picture System were used for emotional stimulation. FMRI measurements covered the whole frontal lobe, activation signals in various frontal cortical regions were obtained, and functional connectivity between the different prefrontal cortical regions was investigated using structural equation modeling. Catatonic patients showed alterations in the orbitofrontal cortical activation pattern and in functional connectivity to the premotor cortex in negative and positive emotions compared to psychiatric and healthy controls. Catatonic behavioral and affective symptoms correlated significantly with orbitofrontal activity, whereas catatonic motor symptoms were rather related to medial prefrontal activity. It is concluded that catatonic symptoms may be closely related to dysfunction in the orbitofrontal cortex and consequent alteration in the prefrontal cortical network during emotional processing. Because we investigated postacute patients, orbitofrontal cortical alterations may be interpreted as a trait marker predisposing for development of catatonic syndrome in schizophrenic or affective psychosis.
原文英語
頁(從 - 到)405-427
頁數23
期刊Schizophrenia Bulletin
30
發行號2
出版狀態已發佈 - 2004

ASJC Scopus subject areas

  • 精神病學和心理健康
  • 神經科學 (全部)

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