Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury: A systematic review and meta-analysis

Chu Ting Chen, Ling Yin Chang, Ching Wei Chuang, Shih Ching Wang, Ming Chang Kao, I. Shiang Tzeng, Ko Lin Kuo, Chin Chieh Wu, Pei Shan Tsai, Chun Jen Huang

研究成果: 雜誌貢獻文章

摘要

Objective: The optimal measuring timing of serum/plasma Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We elucidated further on this issue. Methods: We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating diagnostic accuracy of CysC for detecting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. Results: A total of 10 relevant studies, comprising 2554 patients, were included and divided into the <24 -h and 24 -h groups based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24 -h and 24 -h groups was 7.59 (95 % confidence interval [CI]: 1.31–44.08) and 53.81 (95 % CI: 13.57–213.26). Pooled sensitivity of the <24 -h and 24 -h groups was 0.81 and 0.88. Pooled specificity of the <24 -h and 24 -h groups was 0.64 and 0.88, respectively. Area under the hierarchical summary receiver operating characteristic curve of the <24 -h and 24 -h groups was 0.75 and 0.93. Conclusions: Measuring CysC at 24 h after contrast agent exposure shows higher diagnostic accuracy for early detection of CIAKI than measuring CysC at <24 h after contrast agent exposure.

原文英語
頁(從 - 到)65-73
頁數9
期刊Toxicology Letters
318
DOIs
出版狀態已發佈 - 一月 2020

指紋

Cystatin C
Acute Kidney Injury
Meta-Analysis
Contrast Media
Peripheral Catheterization
Confidence Intervals
Cardiac Catheterization
PubMed
MEDLINE
ROC Curve
Creatinine
Odds Ratio
Plasmas
Serum

ASJC Scopus subject areas

  • Toxicology

引用此文

Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury : A systematic review and meta-analysis. / Chen, Chu Ting; Chang, Ling Yin; Chuang, Ching Wei; Wang, Shih Ching; Kao, Ming Chang; Tzeng, I. Shiang; Kuo, Ko Lin; Wu, Chin Chieh; Tsai, Pei Shan; Huang, Chun Jen.

於: Toxicology Letters, 卷 318, 01.2020, p. 65-73.

研究成果: 雜誌貢獻文章

Chen, Chu Ting ; Chang, Ling Yin ; Chuang, Ching Wei ; Wang, Shih Ching ; Kao, Ming Chang ; Tzeng, I. Shiang ; Kuo, Ko Lin ; Wu, Chin Chieh ; Tsai, Pei Shan ; Huang, Chun Jen. / Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury : A systematic review and meta-analysis. 於: Toxicology Letters. 2020 ; 卷 318. 頁 65-73.
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title = "Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury: A systematic review and meta-analysis",
abstract = "Objective: The optimal measuring timing of serum/plasma Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We elucidated further on this issue. Methods: We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating diagnostic accuracy of CysC for detecting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. Results: A total of 10 relevant studies, comprising 2554 patients, were included and divided into the <24 -h and 24 -h groups based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24 -h and 24 -h groups was 7.59 (95 {\%} confidence interval [CI]: 1.31–44.08) and 53.81 (95 {\%} CI: 13.57–213.26). Pooled sensitivity of the <24 -h and 24 -h groups was 0.81 and 0.88. Pooled specificity of the <24 -h and 24 -h groups was 0.64 and 0.88, respectively. Area under the hierarchical summary receiver operating characteristic curve of the <24 -h and 24 -h groups was 0.75 and 0.93. Conclusions: Measuring CysC at 24 h after contrast agent exposure shows higher diagnostic accuracy for early detection of CIAKI than measuring CysC at <24 h after contrast agent exposure.",
keywords = "AKI, Biomarker, Contrast agent, Creatinine, Cystatin C, Contrast Media/adverse effects, Predictive Value of Tests, Reproducibility of Results, Humans, Middle Aged, Acute Kidney Injury/blood, Male, Cystatin C/blood, Time Factors, Biomarkers/blood, Female, Aged, Early Diagnosis",
author = "Chen, {Chu Ting} and Chang, {Ling Yin} and Chuang, {Ching Wei} and Wang, {Shih Ching} and Kao, {Ming Chang} and Tzeng, {I. Shiang} and Kuo, {Ko Lin} and Wu, {Chin Chieh} and Tsai, {Pei Shan} and Huang, {Chun Jen}",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2020",
month = "1",
doi = "10.1016/j.toxlet.2019.10.011",
language = "English",
volume = "318",
pages = "65--73",
journal = "Toxicology Letters",
issn = "0378-4274",
publisher = "Elsevier BV",

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TY - JOUR

T1 - Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury

T2 - A systematic review and meta-analysis

AU - Chen, Chu Ting

AU - Chang, Ling Yin

AU - Chuang, Ching Wei

AU - Wang, Shih Ching

AU - Kao, Ming Chang

AU - Tzeng, I. Shiang

AU - Kuo, Ko Lin

AU - Wu, Chin Chieh

AU - Tsai, Pei Shan

AU - Huang, Chun Jen

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2020/1

Y1 - 2020/1

N2 - Objective: The optimal measuring timing of serum/plasma Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We elucidated further on this issue. Methods: We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating diagnostic accuracy of CysC for detecting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. Results: A total of 10 relevant studies, comprising 2554 patients, were included and divided into the <24 -h and 24 -h groups based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24 -h and 24 -h groups was 7.59 (95 % confidence interval [CI]: 1.31–44.08) and 53.81 (95 % CI: 13.57–213.26). Pooled sensitivity of the <24 -h and 24 -h groups was 0.81 and 0.88. Pooled specificity of the <24 -h and 24 -h groups was 0.64 and 0.88, respectively. Area under the hierarchical summary receiver operating characteristic curve of the <24 -h and 24 -h groups was 0.75 and 0.93. Conclusions: Measuring CysC at 24 h after contrast agent exposure shows higher diagnostic accuracy for early detection of CIAKI than measuring CysC at <24 h after contrast agent exposure.

AB - Objective: The optimal measuring timing of serum/plasma Cystatin C (CysC) for early detection of contrast-induced acute kidney injury (CIAKI) remains un-studied. We elucidated further on this issue. Methods: We searched PubMed, MEDLINE, and Embase from inception until March 2018 for studies evaluating diagnostic accuracy of CysC for detecting CIAKI in patients exposed to contrast agents during diagnostic examinations or cardiac/peripheral catheterizations. Results: A total of 10 relevant studies, comprising 2554 patients, were included and divided into the <24 -h and 24 -h groups based on CysC measuring timing (i.e., hours after contrast agent exposure). Compared with creatinine, pooled diagnostic odds ratio of CysC for detecting CIAKI of the <24 -h and 24 -h groups was 7.59 (95 % confidence interval [CI]: 1.31–44.08) and 53.81 (95 % CI: 13.57–213.26). Pooled sensitivity of the <24 -h and 24 -h groups was 0.81 and 0.88. Pooled specificity of the <24 -h and 24 -h groups was 0.64 and 0.88, respectively. Area under the hierarchical summary receiver operating characteristic curve of the <24 -h and 24 -h groups was 0.75 and 0.93. Conclusions: Measuring CysC at 24 h after contrast agent exposure shows higher diagnostic accuracy for early detection of CIAKI than measuring CysC at <24 h after contrast agent exposure.

KW - AKI

KW - Biomarker

KW - Contrast agent

KW - Creatinine

KW - Cystatin C

KW - Contrast Media/adverse effects

KW - Predictive Value of Tests

KW - Reproducibility of Results

KW - Humans

KW - Middle Aged

KW - Acute Kidney Injury/blood

KW - Male

KW - Cystatin C/blood

KW - Time Factors

KW - Biomarkers/blood

KW - Female

KW - Aged

KW - Early Diagnosis

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U2 - 10.1016/j.toxlet.2019.10.011

DO - 10.1016/j.toxlet.2019.10.011

M3 - Article

C2 - 31654803

AN - SCOPUS:85074364347

VL - 318

SP - 65

EP - 73

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

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