Optimal design of microneedles inserts into skin by numerical simulation

Chui Yu Chiu, Hsin Chuan Kuo, Yi Lin, Jeou Long Lee, Yung Kang Shen, Sheng Jie Kang

研究成果: 書貢獻/報告類型會議貢獻

3 引文 斯高帕斯(Scopus)

摘要

The purpose of this research is to find the optimal design for biodegradable polymer microneedle patches. Based on the mechanical properties of different skin layers and the failure criterion of the material, this research designs a microneedle of four types and three sizes, then discusses the insertion force and the variation of stress during the process of PLA microneedle insertion into skin by numerical simulation. This research uses the dynamic finite element software ANSYS / LS-DYNA to simulate the processing for PLA microneedle inserts into skin. The master microneedle array was fabricated by the MEMS process. This research uses PDMS to fabricate the mould for microneedles. Finally, a biodegradable polymer polylactic acid (PLA) microneedle patch was fabricated using a PDMS mould micro hot embossing method.
原文英語
主出版物標題Key Engineering Materials
頁面624-628
頁數5
516
DOIs
出版狀態已發佈 - 2012
事件4th International Conference of Asian Society for Precision Engineering and Nanotechnology, ASPEN 2011 - Hong Kong, 中国
持續時間: 十一月 16 2011十一月 18 2011

出版系列

名字Key Engineering Materials
516
ISSN(列印)10139826

其他

其他4th International Conference of Asian Society for Precision Engineering and Nanotechnology, ASPEN 2011
國家中国
城市Hong Kong
期間11/16/1111/18/11

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • 引用此

    Chiu, C. Y., Kuo, H. C., Lin, Y., Lee, J. L., Shen, Y. K., & Kang, S. J. (2012). Optimal design of microneedles inserts into skin by numerical simulation. 於 Key Engineering Materials (卷 516, 頁 624-628). (Key Engineering Materials; 卷 516). https://doi.org/10.4028/www.scientific.net/KEM.516.624