Open-angle glaucoma and the risk of stroke development: A 5-year population-based follow-up study

Jau D. Ho, Chao Chien Hu, Herng Ching Lin

研究成果: 雜誌貢獻文章

25 引文 (Scopus)

摘要

BACKGROUND AND PURPOSE-: Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. METHODS-: Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (n=4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, n=20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. RESULTS-: Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. CONCLUSIONS-: Patients with OAG demonstrated a significantly increased risk of stroke development during the 5-year follow-up period.

原文英語
頁(從 - 到)2685-2690
頁數6
期刊Stroke
40
發行號8
DOIs
出版狀態已發佈 - 八月 2009

指紋

Open Angle Glaucoma
Stroke
Population
Taiwan
Survival Rate
Geographic Locations
National Health Programs
International Classification of Diseases
Comorbidity
Cohort Studies
Demography
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

引用此文

Open-angle glaucoma and the risk of stroke development : A 5-year population-based follow-up study. / Ho, Jau D.; Hu, Chao Chien; Lin, Herng Ching.

於: Stroke, 卷 40, 編號 8, 08.2009, p. 2685-2690.

研究成果: 雜誌貢獻文章

@article{29053f8ab7d842b2b3a5e2268bf048d8,
title = "Open-angle glaucoma and the risk of stroke development: A 5-year population-based follow-up study",
abstract = "BACKGROUND AND PURPOSE-: Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. METHODS-: Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (n=4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, n=20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. RESULTS-: Stroke developed in 14.9{\%} of patients with OAG and 9.5{\%} of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95{\%} CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. CONCLUSIONS-: Patients with OAG demonstrated a significantly increased risk of stroke development during the 5-year follow-up period.",
keywords = "Epidemiology, Open-angle glaucoma, Risk factors, Stroke",
author = "Ho, {Jau D.} and Hu, {Chao Chien} and Lin, {Herng Ching}",
year = "2009",
month = "8",
doi = "10.1161/STROKEAHA.109.554642",
language = "English",
volume = "40",
pages = "2685--2690",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Open-angle glaucoma and the risk of stroke development

T2 - A 5-year population-based follow-up study

AU - Ho, Jau D.

AU - Hu, Chao Chien

AU - Lin, Herng Ching

PY - 2009/8

Y1 - 2009/8

N2 - BACKGROUND AND PURPOSE-: Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. METHODS-: Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (n=4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, n=20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. RESULTS-: Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. CONCLUSIONS-: Patients with OAG demonstrated a significantly increased risk of stroke development during the 5-year follow-up period.

AB - BACKGROUND AND PURPOSE-: Although open-angle glaucoma (OAG) is associated with some of the risk factors of stroke development, there is still no published study addressing whether OAG increases the risk of stroke development. We investigated the risk of stroke development after a diagnosis of OAG. METHODS-: Data were retrospectively collected from the Taiwan National Health Insurance Research Database, which is comprised of 1 073 891 random subjects from among Taiwan's 23 million residents. The study cohort comprised all patients with a diagnosis of OAG (International Classification of Diseases, 9th Revision, Clinical Modification code 365.1 to 365.11) in 2001 (n=4032). The comparison cohort was comprised of randomly selected patients (5 for every patient with OAG, n=20 160) matched with the study group in terms of age, gender, geographic location, and comorbid medical disorders. Patients were tracked from their index visits for 5 years. Cox proportional hazard regression was used to compute the 5-year stroke-free survival rate after adjusting for possible confounding factors. RESULTS-: Stroke developed in 14.9% of patients with OAG and 9.5% of patients in the comparison cohort during the 5-year follow-up period. Patients with OAG had significantly lower 5-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics and selected comorbidities, patients with OAG were found to have a 1.52-fold (95% CI, 1.40 to 1.72) higher risk of having a stroke than the matched comparison cohort. CONCLUSIONS-: Patients with OAG demonstrated a significantly increased risk of stroke development during the 5-year follow-up period.

KW - Epidemiology

KW - Open-angle glaucoma

KW - Risk factors

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=68749086165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68749086165&partnerID=8YFLogxK

U2 - 10.1161/STROKEAHA.109.554642

DO - 10.1161/STROKEAHA.109.554642

M3 - Article

C2 - 19461039

AN - SCOPUS:68749086165

VL - 40

SP - 2685

EP - 2690

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 8

ER -