One-year soy isoflavone supplementation prevents early postmenopausal bone loss but without a dose-dependent effect

Hui Ying Huang, Hsiao Ping Yang, Hui Ting Yang, Tung Chuan Yang, Ming-Che Hsieh, Shih Yi Huang

研究成果: 雜誌貢獻文章同行評審

36 引文 斯高帕斯(Scopus)


It is believed that soy isoflavone has much potential effectiveness on the postmenopausal status; however, the optimal dose for preventing postmenopausal bone loss still remains unclear. This open-labeled, self-controlled pilot study was undertaken to determine the effect of 1-year supplementation of different high dosages of soy isoflavone in postmenopausal Taiwanese women. Forty-three women aged 45-67 years were enrolled and randomly assigned into a control (C), 100 mg/day isoflavone (IF100) and 200 mg/day isoflavone (IF200) groups for 1 year. Dual-energy X-ray absorptiometry and other related biochemical markers of bone metabolism were measured. Results indicated that the decrease in bone mineral density (BMD) was significant for lumbar vertebrae L1-3, L1-4 and the femur neck in the C group; surprisingly, the BMD of L1-3 was significantly elevated in the IF100 group; however, there were no consistent responses in the IF200 group. No significant change except loss of the bone mineral content of Ward's triangle (P=.003) was found in the IF200 group after treatment. The percentage change at L1-3 was less (P=.04) in the IF200 group when compared to the IF100 group. A relatively uniform direction of bone formation in expanding the weight and area with different rates of change resulted in different BMD changes. Both indicated a change of bone formation patterns with the higher-dose supplement. A protective effect of IF100 on estrogen-related bone loss was observed. A lack of a benefit such as high safety in the IF200 group for 1-year administration was ensured and lacked undesirable side effects.
頁(從 - 到)509-517
期刊Journal of Nutritional Biochemistry
出版狀態已發佈 - 8月 2006

ASJC Scopus subject areas

  • 生物化學
  • 內分泌學、糖尿病和代謝


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