One-pot synthesis of luotonin A and its analogues

Ming Chung Tseng, Yu Wan Chu, Hsiang Ping Tsai, Chun Mao Lin, Jaulang Hwang, Yen Ho Chu

研究成果: 雜誌貢獻文章同行評審

64 引文 斯高帕斯(Scopus)

摘要

Starting with inexpensive reagents, a self-directed chemical process with the aid of a single metal triflate was readily achieved to concomitantly construct quinazoline and pyrroloquinoline cores to afford the synthesis of luotonin A and its analogues. Among all compounds prepared, 2c, 2d, and 3b exhibit more potent inhibitory activity than luotonin A against human topoisomerase I.(Figure Presented)

原文英語
頁(從 - 到)920-923
頁數4
期刊Organic Letters
13
發行號5
DOIs
出版狀態已發佈 - 三月 4 2011

ASJC Scopus subject areas

  • 有機化學
  • 物理與理論化學
  • 生物化學

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