OnabotulinumtoxinA improves tactile and mechanical pain perception in painful diabetic polyneuropathy

Wei Ta Chen, Rey-Yue Yuan, Shu Chiung Chiang, Jau-Jiuan Sheu, Jia Ming Yu, Ing Jy Tseng, Szu Kuan Yang, Hsiu Hui Chang, Chaur-Jong Hu

研究成果: 雜誌貢獻文章同行評審

17 引文 斯高帕斯(Scopus)


OBJECTIVES:: Diabetic neuropathic pain may be relieved by onabotulinumtoxinA (BoNT/A). However, whether BoNT/A changes sensory perception in neuropathic patients remains unknown. This study used a double-blind crossover design to explore the possible effect of BoNT/A on sensory perception. METHODS:: Eighteen patients with painful diabetic polyneuropathy underwent 2 consecutive 12-week periods of treatment either in the sequence of saline (control) and then BoNT/A (SB cohort, n=9) or BoNT/A followed by saline (BS cohort, n=9). Sensory perception was assessed according to the tactile threshold [TT, logarithmized force (g) of von Frey filaments] and mechanical pain threshold [PT, logarithmized weight (g) of weighted syringes], both being averages from 4 individual measurements of bilateral medial and lateral feet obtained at baseline (before injections) and at weeks 1, 4, 8, and 12 after treatment. RESULTS:: In either the SB or the BS cohort, there was a decrease in the TT and the PT after treatment with BoNT/A but not with saline. In the analysis merging both cohorts (n=18), BoNT/A resulted in a significant decrease in TT and PT at weeks 1, 4, 8, and 12 (all Ps<0.05 vs. saline). The longitudinal effect of BoNT/A on TT and PT remained significant when baseline values, treatment sequences, and periods were controlled using generalized estimating equations. DISCUSSION:: BoNT/A may improve tactile and mechanical pain perception in painful diabetic polyneuropathy. The beneficial effects of BoNT/A deserves further study to elucidate the exact mechanism and potential for preventing insensate injuries.
頁(從 - 到)305-310
期刊Clinical Journal of Pain
出版狀態已發佈 - 四月 2013

ASJC Scopus subject areas

  • 麻醉與疼痛醫學
  • 神經病學(臨床)


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