Omental fat receptor interacting protein 140 mRNA expression in women with polycystic ovary syndrome

Kok Min Seow, Yieh Loong Tsai, Chi Chang Juan, Lee Wen Huang, Jiann Loung Hwang, Low Tone Ho

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Background: Receptor interacting protein 140 (RIP140) is a co-repressor and essential for oocytes released by the ovary during ovulation. The aim of the study is to investigate adipose mRNA expression of RIP140 in women with polycystic ovary syndrome (PCOS) before and 3 months after laparoscopic ovarian electrocauterization (LOE). Methods: Adipose tissues obtained from 15 women with PCOS before and after LOE were analyzed. Ten lean, age- and BMI-matched non-PCOS women served as controls. Gene expression of RIP140 was quantified by reverse transcriptase-polymerase chain reaction. Results: The overall spontaneous ovulation rate was 73.3% in PCOS after the LOE procedure. However, no difference was found in the expression of RIP140 between women with PCOS before LOE and controls or between PCOS before and after LOE. No difference was found in RIP140 expression between obese and lean women with PCOS, or between obese PCOS and lean controls. Further, there was no correlation between RIP140 and fasting or 2-hour glucose or insulin, homeostasis model insulin resistance index (HOMAIR), and fasting glucose-to-insulin ratio (G 0/I0) in women with PCOS. Conclusion: RIP140 gene does not play any pivotal role in the process of ovulation, insulin resistance or fat accumulation in women with PCOS.
原文英語
頁(從 - 到)51-56
頁數6
期刊Gynecologic and Obstetric Investigation
69
發行號1
DOIs
出版狀態已發佈 - 1月 2010

ASJC Scopus subject areas

  • 婦產科
  • 生殖醫學

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