Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo; Ara Ghazaryan; Chien Hsin Tso; Po Sheng Hu; Wei Liang Chen; Tsung Rong Kuo; Sung Jan Lin; Shean Jen Chen; Chia Chun Chen; Chen Yuan Dong

doi:10.1063/1.3701135

Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien Hsin Tso, Po Sheng Hu, Wei Liang Chen, Tsung Rong Kuo, Sung Jan Lin, Shean Jen Chen, Chia Chun Chen, Chen Yuan Dong

研究成果: 雜誌貢獻 › 文章 › 同行評審

3 引文斯高帕斯（Scopus）

摘要

Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

原文	英語
文章編號	213701
期刊	Applied Physics Letters
卷	100
發行號	21
DOIs	https://doi.org/10.1063/1.3701135
出版狀態	已發佈 - 5月 21 2012
對外發佈	是

ASJC Scopus subject areas

物理與天文學（雜項）

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10.1063/1.3701135

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title = "Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles",

abstract = "Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.",

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AU - Lo, Wen

AU - Ghazaryan, Ara

AU - Tso, Chien Hsin

AU - Hu, Po Sheng

AU - Chen, Wei Liang

AU - Kuo, Tsung Rong

AU - Lin, Sung Jan

AU - Chen, Shean Jen

AU - Chen, Chia Chun

AU - Dong, Chen Yuan

PY - 2012/5/21

Y1 - 2012/5/21

N2 - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

AB - Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.

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Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

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