Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles

Wen Lo, Ara Ghazaryan, Chien Hsin Tso, Po Sheng Hu, Wei Liang Chen, Tsung Rong Kuo, Sung Jan Lin, Shean Jen Chen, Chia Chun Chen, Chen Yuan Dong

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)


Transdermal delivery of nanocarriers provides an alternative pathway to transport therapeutic agents, alleviating pain, improving compliance of patients, and increasing overall effectiveness of delivery. In this work, enhancement of transdermal delivery of fluorescent nanoparticles and sulforhodamine B with assistance of oleic acid was visualized utilizing multiphoton microscopy (MPM) and analyzed quantitatively using multi-photon excitation-induced fluorescent signals. Results of MPM imaging and MPM intensity-based spatial depth-dependent analysis showed that oleic acid is effective in facilitating transdermal delivery of nanoparticles.
期刊Applied Physics Letters
出版狀態已發佈 - 五月 21 2012


ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


Lo, W., Ghazaryan, A., Tso, C. H., Hu, P. S., Chen, W. L., Kuo, T. R., Lin, S. J., Chen, S. J., Chen, C. C., & Dong, C. Y. (2012). Oleic acid-enhanced transdermal delivery pathways of fluorescent nanoparticles. Applied Physics Letters, 100(21), [213701]. https://doi.org/10.1063/1.3701135