Office-based salivary gland ductal irrigation in patients with chronic sialoadenitis: A preliminary study

Yen Chun Chen, Luong Huu Dang, Lung Che Chen, Chi Ching Chang, Deng Yu Han, Chung Huei Hsu, Yi Fang Ding, Chin Hui Su, Shih Han Hung

研究成果: 雜誌貢獻文章同行評審

摘要

Background/Purpose: To evaluate the therapeutic responsiveness of office-based salivary gland ductal irrigation in patients with chronic sialoadenitis. Methods: Between August 2017 and April 2019, 55 patients comprising the following three disease groups were enrolled: Sjogren's syndrome: 39 patients; postradiotherapy sialoadenitis: ten patients; and post-RAI sialoadenitis: six patients. Quantitative salivary scintigraphy was recorded, and a formulated questionnaire including the Summated Xerostomia Inventory was utilized to assess acute/chronic symptoms. All patients received at least three serial salivary gland ductal irrigations with a one-month interval in our outpatient department. Results: The general response rates for each disease groups are as follows: Sjogren's syndrome: 61.5% (24/39); postradiotherapy: 60% (6/10); and post-RAI: 83.3% (5/6). Among the patients with Sjogren's syndrome, the parotid scintigraphic Tmin showed a significant positive correlation with the responsiveness of salivary irrigation (P = 0.046), whereas the treatment tended to be irresponsive in patients who previously took medicine for their related discomfort (P = 0.009). In the postradiotherapy and post-RAI groups, no significant factors were found to be associated with the responsiveness of irrigation. Conclusion: Simple salivary ductal irrigation without complex equipment can be performed as an outpatient procedure to alleviate glandular swelling or xerostomia in patients with Sjogren's syndrome, postradiotherapy sialoadenitis or post-RAI sialoadenitis, and it can be considered an alternative management approach for patients refractory to conventional strategies.

原文英語
頁(從 - 到)318-326
頁數9
期刊Journal of the Formosan Medical Association
120
發行號1 Pt 2
DOIs
出版狀態已發佈 - 一月 2021

ASJC Scopus subject areas

  • 醫藥 (全部)

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