Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processing

Chian Fang G Cherng, Chun Pi Chang, Chien Chou Su, Wen Yu Tzeng, Jia Ying Chuang, Li Hsien Chen, Kuei Ying Lin, Lung Yu

研究成果: 雜誌貢獻文章

6 引文 (Scopus)

摘要

Unconditioned foot shock followed by restraint in water was used as a stress regimen to induce decreases in neurogenesis in mouse dentate gyrus (DG). Presence of conspecific odors has been known to reverse the stress-induced decrease in DG neurogenesis. In this study, we found that the conspecific odors did not produce these protective effects in mice whose MOE was impaired by nasal zinc sulfate lavage. Moreover, we observed that the presence of odors from rats, hamsters, and guinea pigs throughout the stress procedure reversed the stress-induced decrease in cell proliferation and neurogenesis in mouse dentate gyrus, while these odors alone did not affect mouse dentate cell proliferation or neurogenesis. In contrast, the presence of rabbit, sugar glider, hedgehog, beetle odors did not affect cell proliferation, neurogenesis, the stress-decreased cell proliferation or neurogenesis in DG. Finally, the presence of fox urine odors decreased mouse dentate cell proliferation and neurogenesis but did not affect the stress-induced decrease in cell proliferation or neurogenesis. Taken together, we conclude that olfactory processing via activation of sensory neurons in MOE is responsible for the conspecific odor-produced protective effect against the stress-decreased cell proliferation and neurogenesis. Phylogenetic distances of the odor-generating species and mice might contribute to the odors' protective effects against the stress-induced decreases in cell proliferation and neurogenesis.
原文英語
頁(從 - 到)106-112
頁數7
期刊Behavioural Brain Research
229
發行號1
DOIs
出版狀態已發佈 - 四月 1 2012
對外發佈Yes

指紋

Neurogenesis
Cell Proliferation
Dentate Gyrus
Odorants
Zinc Sulfate
Hedgehogs
Therapeutic Irrigation
Beetles
Sensory Receptor Cells
Nose
Cricetinae
Foot
Shock
Guinea Pigs
Urine
Rabbits
Water

ASJC Scopus subject areas

  • Behavioral Neuroscience

引用此文

Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processing. / Cherng, Chian Fang G; Chang, Chun Pi; Su, Chien Chou; Tzeng, Wen Yu; Chuang, Jia Ying; Chen, Li Hsien; Lin, Kuei Ying; Yu, Lung.

於: Behavioural Brain Research, 卷 229, 編號 1, 01.04.2012, p. 106-112.

研究成果: 雜誌貢獻文章

Cherng, Chian Fang G ; Chang, Chun Pi ; Su, Chien Chou ; Tzeng, Wen Yu ; Chuang, Jia Ying ; Chen, Li Hsien ; Lin, Kuei Ying ; Yu, Lung. / Odors from proximal species reverse the stress-decreased neurogenesis via main olfactory processing. 於: Behavioural Brain Research. 2012 ; 卷 229, 編號 1. 頁 106-112.
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abstract = "Unconditioned foot shock followed by restraint in water was used as a stress regimen to induce decreases in neurogenesis in mouse dentate gyrus (DG). Presence of conspecific odors has been known to reverse the stress-induced decrease in DG neurogenesis. In this study, we found that the conspecific odors did not produce these protective effects in mice whose MOE was impaired by nasal zinc sulfate lavage. Moreover, we observed that the presence of odors from rats, hamsters, and guinea pigs throughout the stress procedure reversed the stress-induced decrease in cell proliferation and neurogenesis in mouse dentate gyrus, while these odors alone did not affect mouse dentate cell proliferation or neurogenesis. In contrast, the presence of rabbit, sugar glider, hedgehog, beetle odors did not affect cell proliferation, neurogenesis, the stress-decreased cell proliferation or neurogenesis in DG. Finally, the presence of fox urine odors decreased mouse dentate cell proliferation and neurogenesis but did not affect the stress-induced decrease in cell proliferation or neurogenesis. Taken together, we conclude that olfactory processing via activation of sensory neurons in MOE is responsible for the conspecific odor-produced protective effect against the stress-decreased cell proliferation and neurogenesis. Phylogenetic distances of the odor-generating species and mice might contribute to the odors' protective effects against the stress-induced decreases in cell proliferation and neurogenesis.",
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