Obesity and insulin resistance in women with polycystic ovary syndrome

Hsu Chun-Sen, Wu Chien-Hua, Chiu Wan-Chun, Lee Ching-Tzu, Chang Chun-Jen, Hsu Ming-I

研究成果: 雜誌貢獻文章同行評審

18 引文 斯高帕斯(Scopus)

摘要

Objective. To evaluate the impact of obesity and various phenotypes of polycystic ovary syndrome (PCOS) on the insulin sensitivity index (ISI) and insulin resistance (IR). Methods. ISI and IR from 273 women in four phenotypes of PCOS and control groups were evaluated retrospectively. Results. The ISI and the percentage of IR were not significantly different among discrete phenotypes of PCOS groups and normal controls. Obesity (OR = 14.0, 95% CI (Confidence Interval), 7.5-26.5) results in a higher risk for developing insulin resistance than hyperandrogenemia (OR = 2.1, 1.3-3.6), oligomenorrhea (OR = 1.8, 1.0-3.3) and polycystic ovary morphology (PCOM) (OR = 1.4, 0.8-2.7). Conclusion. The ISI did not differ significantly among the various phenotypes of PCOS. In comparison with hyperandrogenemia, chronic anovulation, and PCOM, obesity was the dominant risk factor in determining insulin resistance in women with PCOS.

原文英語
頁(從 - 到)300-306
頁數7
期刊Gynecological Endocrinology
27
發行號5
DOIs
出版狀態已發佈 - 五月 2011

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology

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