Nuclear expression of BCL10 or nuclear factor kappa B helps predict Helicobacter pylori-independent status of low-grade gastric mucosa-associated lymphoid tissue lymphomas with or without t(11;18)(q21;q21 )

Kun Huei Yeh, Sung Hsin Kuo, Li Tzong Chen, Tsui Lien Mao, Shin Lian Doong, Ming Shiang Wu, Hui Chen Hsu, Yi Shin Tzeng, Chi Long Chen, Jaw Town Lin, Ann Lii Cheng

研究成果: 雜誌貢獻文章

63 引文 斯高帕斯(Scopus)

摘要

The t(11;18)(q21;q21) translocation is a specific marker for Helicobacter pylori-independent-status of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, there are no reliable markers to predict tumor response to H pylori eradication in patients without t(11;18)(q21;q21). Nuclear expression of BCL10 and nuclear factor kappa B (NF-κB) was recently found to be closely associated with Hpylori-independent status of the high-grade counterpart of gastric MALT lymphoma, which usually lacks t(11;18)(q21;q21). This study examined whether these 2 markers can also predict H pylori-independent status of low-grade gastric MALT lymphomas without t(11; 18)(q21;q21). Sixty patients who underwent successful H pylori eradication for low-grade gastric MALT lymphomas were included. Forty-seven (78.3%) patients were negative for t(11;18)(q21;q21); among them, 36 (76.6%) were H pylori dependent and 11 (23.4%) were H pylori independent. Nuclear expression of BCL10 was significantly higher in H pylori-independent than in H pylori-dependent tumors (8 of 11 [72.7%] vs 3 of 36 [8.3%]; P <.001). Nuclear expression of NF-κB was also significantly higher in H pylori-independent than in H pylori-dependent tumors (7 of 11 [63.6%] vs 3 of 36 [8.3%]; P <.001). Further, nuclear translocation of BCL10 and NF-κB was observed in 12 of the 13 patients with t(11;18)(q21;q21), and all these 12 patients were H pylori independent. In summary, nuclear expression of BCL10 or NF-κB is predictive of H pylori-independent status of low-grade gastric MALT lymphoma with or without t(11;18)(q21; q21).

原文英語
頁(從 - 到)1037-1041
頁數5
期刊Blood
106
發行號3
DOIs
出版狀態已發佈 - 八月 1 2005

ASJC Scopus subject areas

  • Hematology

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