We have studied the effects of N6-(Δ2-isopentenyl)adenosine and related cytokinin analogs on the stimulation and inhibition of phytohemagglutinin-induced growth of human lymphocytes. We have found that N6-(Δ2-isopentenyl)adenosine exerts inhibitory effects on RNA synthesis, uridine transport and uridylate kinase synthesis. On the basis of the interaction of N6-(Δ2-isopentenyl)adenosine with cyclic AMP in this system, we propose that the observed stimulatory and inhibitory effects may be due to the involvement of N6-(Δ2-isopentenyl)adenosine in cyclic AMP metabolism.
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Gallo, R. C., Hecht, S. M., Whang-Peng, J., & O'Hopp, S. (1972). N6-(Δ2-isopentenyl)adenosine: The regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes. BBA Section Nucleic Acids And Protein Synthesis, 281(4), 488-500. https://doi.org/10.1016/0005-2787(72)90149-9