N6-(Δ2-isopentenyl)adenosine: The regulatory effects of a cytokinin and modified nucleoside from tRNA on human lymphocytes

Robert C. Gallo, Sidney M. Hecht, Jacqueline Whang-Peng, Susan O'Hopp

研究成果: 雜誌貢獻文章同行評審

11 引文 斯高帕斯(Scopus)

摘要

We have studied the effects of N6-(Δ2-isopentenyl)adenosine and related cytokinin analogs on the stimulation and inhibition of phytohemagglutinin-induced growth of human lymphocytes. We have found that N6-(Δ2-isopentenyl)adenosine exerts inhibitory effects on RNA synthesis, uridine transport and uridylate kinase synthesis. On the basis of the interaction of N6-(Δ2-isopentenyl)adenosine with cyclic AMP in this system, we propose that the observed stimulatory and inhibitory effects may be due to the involvement of N6-(Δ2-isopentenyl)adenosine in cyclic AMP metabolism.
原文英語
頁(從 - 到)488-500
頁數13
期刊BBA Section Nucleic Acids And Protein Synthesis
281
發行號4
DOIs
出版狀態已發佈 - 十一月 9 1972
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

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