Novel SNPs in a candidate gene, CRTH2, for allergic diseases

S. C. Hsu, L. C. Chen, M. L. Kuo, J. Long Huang, S. K. Huang

研究成果: 雜誌貢獻文章

13 引文 斯高帕斯(Scopus)

摘要

Sequencing analyses of genomic DNA samples from a Chinese population identified four single-nucleotide polymorphisms (SNPs) of the CRTH2 gene, encoding a chemoattractant receptor predominantly expressed on Th2 cells and a receptor for prostaglandin D2 (PGD2). Two coding-region SNPs with a T to G and a C to A substitutions, resulting in codon changes from Phe to Val and Pro to Thr, respectively. Two additional SNPs were discovered in the 3′ untranslated region (3′-UTR). These newly identified SNPs will be useful for further functional study of variant CRTH2 gene, and for genetic studies of asthma and other immunologic diseases.

原文英語
頁(從 - 到)114-116
頁數3
期刊Genes and Immunity
3
發行號2
DOIs
出版狀態已發佈 - 四月 1 2002
對外發佈Yes

ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

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