Novel method to prepare biological samples using powerful magnets on TOF-SIMS analysis

Chun-Chao Chang, Chun Nan Chen, Wei Jhih Lin, Tsui Yun Lo, Shiou Ling Lei, Fu-Der Mai

研究成果: 雜誌貢獻文章同行評審

2 引文 斯高帕斯(Scopus)

摘要

Imaging with time-of-flight secondary ion mass spectrometry (TOF-SIMS) has been shown to be a powerful analytical tool for mapping the distribution of biologically relevant small molecules (<1000 Da) on a surface. To improve the success rate of sample preparation, a device was designed to cells freeze-fracture by using powerful magnets. Quantum dots (QDs) were used to observe the changes in the cell after freeze-fracture. Then, TOF-SIMS was employed to analyze the ionic and molecular distribution in the cells associated with the disease.
原文英語
頁(從 - 到)248-250
頁數3
期刊Surface and Interface Analysis
45
發行號1
DOIs
出版狀態已發佈 - 一月 2013

ASJC Scopus subject areas

  • 化學 (全部)
  • 凝聚態物理學
  • 表面和介面
  • 材料化學
  • 表面、塗料和薄膜

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