Novel inhibitors of poly(ADP-ribose) glycohydrolase

Kazuma Aoki, Koji Nishimura, Hideaki Abe, Hideharu Maruta, Hiroshi Sakagami, Tsutomu Hatano, Takuo Okuda, Takashi Yoshida, Yan Jyu Tsai, Fumiaki Uchiumi, Sei ichi Tanuma

研究成果: 雜誌貢獻文章同行評審

48 引文 斯高帕斯(Scopus)

摘要

The inhibitory effects on poly(ADP-ribose) glycohydrolase purified from human placenta of three classes of chemically defined tannins; gallotannins; ellagitannins and condensed tannins, were examined in vitro. Oligometric ellagitannins were found to be most potent inhibitors of poly(ADP-ribose) glycohydrolase, their potencies increasing with increasing number of monomeric residues (dinner <trimer <tetramer). Monomeric ellagitannins and gallotannins were less inhibitory. Condensed tannins, which consist of an epicatechin gallate oligomer without a glucose core, were not appreciably inhibitory. A structure-activity study showed that higher-order confirmations of the conjugates with glucose of hexahydroxydiphenoyl and valoneoyl groups, which are unique components of ellegitannins, cooperatively potentiated the inhibitory activity.
原文英語
頁(從 - 到)251-256
頁數6
期刊Biochimica et Biophysica Acta - General Subjects
1158
發行號3
DOIs
出版狀態已發佈 - 11月 28 1993

ASJC Scopus subject areas

  • 生物物理學
  • 生物化學
  • 分子生物學

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