Novel GM-CSF-based vaccines: One small step in GM-CSF gene optimization, one giant leap for human vaccines

Ting Wei Yu, Ho Yen Chueh, Ching Chou Tsai, Cheng Tao Lin, Jiantai Timothy Qiu

研究成果: 雜誌貢獻回顧型文獻同行評審

18 引文 斯高帕斯(Scopus)

摘要

Granulocyte macrophage-colony stimulating factor (GM-CSF) is a potent immunomodulatory cytokine that is known to facilitate vaccine efficacy by promoting the development and prolongation of both humoral and cellular immunity. In the past years we have generated a novel codon-optimized GM-CSF gene as an adjuvant. The codon-optimized GM-CSF gene significantly increased protein expression levels in all cells tested and helped in generating a strong immune responses against HIV-1 Gag and HPV-associated cancer. Here, we review the literature dealing with the adjuvant activity of GM-CSF both in animal models and clinical trials. We anticipate that the codon-optimized GM-CSF gene offers a practical molecular strategy for potentiating immune responses to tumor cell-based vaccinations as well as other immunotherapeutic strategies.

原文英語
頁(從 - 到)3020-3028
頁數9
期刊Human Vaccines and Immunotherapeutics
12
發行號12
DOIs
出版狀態已發佈 - 12月 1 2016
對外發佈

ASJC Scopus subject areas

  • 免疫學和過敏
  • 免疫學
  • 藥理

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