Novel ent-beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina

Che Ling Lin, Shwu Jiuan Lin, Wei Jan Huang, Yuan Ling Ku, Tung Hu Tsai, Feng-Lin Hsu

研究成果: 雜誌貢獻文章同行評審

10 引文 斯高帕斯(Scopus)

摘要

Biotransformations of ent-16β-hydroxybeyeran-19-oic acid (1) by Mortierella isabellina produced hydroxylated metabolites. The isolated metabolites included three new compounds, ent-14β,16β- dihydroxybeyeran-19-oic acid (3), ent-12β-hydroxy-16-oxobeyeran-19-oic acid (4), and enr-7α,12β-dihydroxy-16-oxobeyeran-19-oic acid (5), and one known compound, ent-7α,16β-dihydroxybeyeran-19-oic acid (2). The structural elucidation was achieved by detailed analysis of LC-MS chromatograms, and MS and NMR spectroscopic data. In this study, M. isabellina hydroxylated the basic skeleton beyeran-19-oic acid at the 7β-, 12α-, and 14α-positions, and oxidized the skeleton at the 16-position. All compounds were evaluated with the cell viability assay. The results of the bioassay indicated that MTT formazan exocytosis occurs upon treatment of the cells with 1.
原文英語
頁(從 - 到)1581-1587
頁數7
期刊Planta Medica
73
發行號15
DOIs
出版狀態已發佈 - 十二月 2007

Keywords

  • ent-16β-Hydroxybeyeran-19-oic acid
  • Hydroxylation
  • Isoteviol
  • Microbial biotransformations
  • Mortierella isabellina
  • MTT formazan exocytosis
  • Stevioside

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

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