Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells

Ya Chun Lee, Liang Ming Lee, Chih Hsin Yang, Anya Maan Yuh Lin, Yi Chia Huang, Chia Chi Hsu, Meng Shian Chen, Chin Wen Chi, Pen Hui Yin, Cheng Deng Kuo, Jyh Fei Liao, Hsin Chen Lee

研究成果: 雜誌貢獻文章同行評審

19 引文 斯高帕斯(Scopus)

摘要

Norcantharidin is the demethylated analog of cantharidin isolated from blister beetles (Mylabris phalerata Pall.). In this study, we evaluated whether norcantharidin exhibits anticancer effects against the human non-small cell lung cancer cell lines A549 (epidermal growth factor receptor (EGFR) mutation-negative) and PC9 (EGFR mutation-positive). Our results revealed that norcantharidin dose-dependently retards cell growth, arrests cell cycle at G2/M phase, reduces cell migration, and even induces apoptosis at the concentration of 100 μM. Moreover, we found that norcantharidin enhances the anticancer effects of gefitinib and cisplatin. Norcantharidin exhibited similar potency of anticancer effects against the two cell lines with different EGFR mutation status and did not affect EGF-induced EGFR phosphorylation, suggesting that the EGFR signaling may not be the target of norcantharidin. In conclusion, our results suggest that norcantharidin exhibits anticancer effects against non-small cell lung cancer cells in vitro and support its potential as a chemotherapeutic agent for treating non-small cell lung cancer.
原文英語
頁(從 - 到)237-243
頁數7
期刊Oncology Reports
29
發行號1
DOIs
出版狀態已發佈 - 一月 2013
對外發佈

ASJC Scopus subject areas

  • 癌症研究
  • 腫瘤科

指紋

深入研究「Norcantharidin suppresses cell growth and migration with enhanced anticancer activity of gefitinib and cisplatin in human non-small cell lung cancer cells」主題。共同形成了獨特的指紋。

引用此