Nonhistone proteins HMG1 and HMG2 change the DNA helical structure

Kashayar Javaherian; Leroy-Fong Liu; James C. Wang

Nonhistone proteins HMG₁ and HMG₂ change the DNA helical structure

Kashayar Javaherian, Leroy-Fong Liu, James C. Wang

研究成果: 雜誌貢獻 › 文章 › 同行評審

摘要

Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG₁ and HMG₂, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.

原文	英語
頁（從 - 到）	1345-1346
頁數	2
期刊	Science
卷	199
發行號	4335
出版狀態	已發佈 - 1978
對外發佈	Yes

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abstract = "Two chromatin nonhistone proteins (from calf thymus) of the high mobility group, HMG1 and HMG2, reduce the linking number (topological winding number) of a circular DNA if the covalent closure of the DNA is carried out in their presence. This indicates that these proteins can either unwind the double helix, or induce a supercoiling of the DNA.",

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