Nongenomic regulation by thyroid hormone of plasma membrane ion and small molecule pumps.

Hung Yun Lin, Heng Yuan Tang, Faith B. Davis, Shaker A. Mousa, Sandra Incerpi, Mary K. Luidens, Ran Meng, Paul J. Davis

研究成果: 雜誌貢獻回顧型文獻

24 引文 斯高帕斯(Scopus)

摘要

The sodium/proton (Na/H) exchanger, Na,K-ATPase, and Ca2+-ATPase are membrane ion pumps whose basal activities may be regulated by local nongenomic actions of thyroid hormone and hormone analogues via a hormone receptor on plasma membrane integrin αvβ3. System A amino acid transport and the activity of P-glycoprotein (P-gp; ABCB1), a multidrug efflux pump, are also modulated by thyroid hormone and αvβ3. Where signal transduction has been studied, the presence of the hormone at the receptor is transduced by mitogen-activated protein kinase (MAPK) isoforms (ERK1/2; p38) or phosphatidylinositol 3-kinase into local actions. The existence of the cell surface receptor offers opportunities to pharmacologically modify actions of these important transport functions with nanoparticulate formulations of T4 and T3 that do not enter the cell. Such formulations may reverse complex intracellular accumulations of H+, Na+, and Ca2+ that occur in clinical settings such as ischemia. In addition, nanoparticulate tetraiodothyroacetic acid (tetrac), a thyroid hormone analogue that inhibits binding of T4 and T3 to integrin αvβ3 as well as certain other functions of the integrin, may reverse P-gp-dependent resistance to anti-cancer drugs in tumor cells.
原文英語
頁(從 - 到)199-206
頁數8
期刊Discovery medicine
14
發行號76
出版狀態已發佈 - 九月 2012
對外發佈Yes

ASJC Scopus subject areas

  • Medicine(all)

指紋 深入研究「Nongenomic regulation by thyroid hormone of plasma membrane ion and small molecule pumps.」主題。共同形成了獨特的指紋。

  • 引用此

    Lin, H. Y., Tang, H. Y., Davis, F. B., Mousa, S. A., Incerpi, S., Luidens, M. K., Meng, R., & Davis, P. J. (2012). Nongenomic regulation by thyroid hormone of plasma membrane ion and small molecule pumps. Discovery medicine, 14(76), 199-206.