Non-Watson-Crick G. C and A. T Base Pairs in a DNA-antibiotic complex

Gary J. Quigley, Giovanni Ughetto, Gijs A. Van Der Marel, Jacques H. Van Boom, Andrew H.J. Wang, Alexander Rich

研究成果: 雜誌貢獻文章同行評審

124 引文 斯高帕斯(Scopus)

摘要

The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A · T and two G · C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G · C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.

原文英語
頁(從 - 到)1255-1258
頁數4
期刊Science
232
發行號4755
DOIs
出版狀態已發佈 - 1986
對外發佈

ASJC Scopus subject areas

  • 多學科

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