Non-muscular invasive bladder cancer: Re-envisioning therapeutic journey from traditional to regenerative interventions

Kuan Wei Shih, Wei Chieh Chen, Ching Hsin Chang, Ting En Tai, Jeng Cheng Wu, Andy C. Huang, Ming Che Liu

研究成果: 雜誌貢獻回顧型文獻同行評審

摘要

Non-muscular invasive bladder cancer (NMIBC) is one of the most common cancer and major cause of economical and health burden in developed countries. Progression of NMIBC has been characterized as low-grade (Ta) and high grade (carcinoma in situ and T1). The current surgical intervention for NMIBC includes transurethral resection of bladder tumor; however, its recurrence still remains a challenge. The BCG-based immunotherapy is much effective against low-grade NMIBC. BCG increases the influx of T cells at bladder cancer site and inhibits proliferation of bladder cancer cells. The chemotherapy is another traditional approach to address NMIBC by supplementing BCG. Notwithstanding, these current therapeutic measures possess limited efficacy in controlling NMIBC, and do not provide comprehensive long-term relief. Hence, biomaterials and scaffolds seem an effective medium to deliver therapeutic agents for restructuring bladder post-treatment. The regenerative therapies such as stem cells and PRP have also been explored for possible solution to NMIBC. Based on above-mentioned approaches, we have comprehensively analyzed therapeutic journey from traditional to regenerative interventions for the treatment of NMIBC.

原文英語
頁(從 - 到)868-885
頁數18
期刊Aging and Disease
12
發行號3
DOIs
出版狀態已發佈 - 六月 1 2021

ASJC Scopus subject areas

  • 病理學與法醫學
  • 老年病學和老年學
  • 神經病學(臨床)
  • 細胞生物學

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