No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis

Y. T. Chang, W. R. Lee, C. W. Yu, H. N. Liu, M. W. Lin, C. H. Huang, C. C. Chen, D. D. Lee, W. J. Wang, Jun-Hung Hu, S. F. Tsai

研究成果: 雜誌貢獻文章

28 引文 (Scopus)

摘要

Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-α, STAT6, and interferon (IFN)-γ. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.

原文英語
頁(從 - 到)419-423
頁數5
期刊Clinical and Experimental Dermatology
31
發行號3
DOIs
出版狀態已發佈 - 五月 2006

指紋

Atopic Dermatitis
Cytokines
Genes
Genetic Polymorphisms
Transducers
Interleukin-4
Type II Interleukin-4 Receptors
Interleukin-4 Receptors
Th2 Cells
Interleukin-13
Eosinophilia
Skin Diseases
Interleukin-10
Microsatellite Repeats
Interferons
Immunoglobulin E
Tumor Necrosis Factor-alpha
DNA
Serum
Population

ASJC Scopus subject areas

  • Dermatology

引用此文

No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. / Chang, Y. T.; Lee, W. R.; Yu, C. W.; Liu, H. N.; Lin, M. W.; Huang, C. H.; Chen, C. C.; Lee, D. D.; Wang, W. J.; Hu, Jun-Hung; Tsai, S. F.

於: Clinical and Experimental Dermatology, 卷 31, 編號 3, 05.2006, p. 419-423.

研究成果: 雜誌貢獻文章

Chang, YT, Lee, WR, Yu, CW, Liu, HN, Lin, MW, Huang, CH, Chen, CC, Lee, DD, Wang, WJ, Hu, J-H & Tsai, SF 2006, 'No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis', Clinical and Experimental Dermatology, 卷 31, 編號 3, 頁 419-423. https://doi.org/10.1111/j.1365-2230.2006.02124.x
Chang, Y. T. ; Lee, W. R. ; Yu, C. W. ; Liu, H. N. ; Lin, M. W. ; Huang, C. H. ; Chen, C. C. ; Lee, D. D. ; Wang, W. J. ; Hu, Jun-Hung ; Tsai, S. F. / No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis. 於: Clinical and Experimental Dermatology. 2006 ; 卷 31, 編號 3. 頁 419-423.
@article{926b3b2cd79e49ffb18c3afc6db37ec3,
title = "No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis",
abstract = "Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-α, STAT6, and interferon (IFN)-γ. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.",
author = "Chang, {Y. T.} and Lee, {W. R.} and Yu, {C. W.} and Liu, {H. N.} and Lin, {M. W.} and Huang, {C. H.} and Chen, {C. C.} and Lee, {D. D.} and Wang, {W. J.} and Jun-Hung Hu and Tsai, {S. F.}",
year = "2006",
month = "5",
doi = "10.1111/j.1365-2230.2006.02124.x",
language = "English",
volume = "31",
pages = "419--423",
journal = "Clinical and Experimental Dermatology",
issn = "0307-6938",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - No association of cytokine gene polymorphisms in Chinese patients with atopic dermatitis

AU - Chang, Y. T.

AU - Lee, W. R.

AU - Yu, C. W.

AU - Liu, H. N.

AU - Lin, M. W.

AU - Huang, C. H.

AU - Chen, C. C.

AU - Lee, D. D.

AU - Wang, W. J.

AU - Hu, Jun-Hung

AU - Tsai, S. F.

PY - 2006/5

Y1 - 2006/5

N2 - Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-α, STAT6, and interferon (IFN)-γ. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.

AB - Background. Atopic dermatitis (AD) is a common chronically relapsing skin disease associated with the activation of T-helper 2 cells. Recent studies have shown that polymorphisms in the genes for interleukin (IL)-4, the IL-4 receptor, IL-13, and signal transducer and activator 6 (STAT6) may contribute to susceptibility of AD. To date, no cytokine gene polymorphism study has been conducted on Chinese patients with AD. Aims. To determine whether genetic polymorphisms of the cytokine genes might influence the development of AD. Methods. DNA samples were obtained from 94 patients and 186 control subjects. Using direct sequencing and microsatellite genotyping, we examined 22 polymorphisms in eight cytokine genes including the genes for IL-4, -10, -12B and -13, the IL-4 receptor, tumour necrosis factor (TNF)-α, STAT6, and interferon (IFN)-γ. Results. No significantly different allelic and genotypic distributions of the cytokine gene polymorphisms could be found between patients and controls. Moreover, no association was observed with disease onset, gender, the presence of elevated serum total IgE level or blood eosinophilia. Conclusion. Our study suggests that the analysed genetic polymorphisms of cytokine genes do not appear to be associated with AD susceptibility in our Chinese population.

UR - http://www.scopus.com/inward/record.url?scp=33645334935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645334935&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2230.2006.02124.x

DO - 10.1111/j.1365-2230.2006.02124.x

M3 - Article

C2 - 16681592

AN - SCOPUS:33645334935

VL - 31

SP - 419

EP - 423

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

SN - 0307-6938

IS - 3

ER -