NNOS-positive minor-branches of the dorsal penile nerves is associated with erectile function in the bilateral cavernous injury model of rats

Yen Lin Chen, Ting Ting Chao, Yi No Wu, Meng Chuan Chen, Ying Hung Lin, Chun Hou Liao, Chien Chih Wu, Kuo Chiang Chen, Shang Shing P. Chou, Han Sun Chiang

研究成果: 雜誌貢獻文章

3 引文 斯高帕斯(Scopus)

摘要

The changes in neuronal nitric oxide synthases (nNOS) in the dorsal penile nerves (DPNs) are consistent with cavernous nerve (CN) injury in rat models. However, the anatomical relationship and morphological changes between the minor branches of the DPNs and the CNs after injury have never been clearly explored. There were forty 12 week old male Sprague-Dawley rats receiving bilateral cavernous nerve injury (BCNI). Erectile function of intracavernous pressure and mean arterial pressure were measured. The histology and ultrastructure with H&E stain, Masson's trichrome stain and immunohistochemical stains were applied on the examination of CNs and DPNs. We demonstrated communicating nerve branches between the DPNs and the CNs in rats. The greatest damage and lowest erectile function were seen in the 14th day and partially recovered in the 28th day after BCNI. The nNOS positive DPN minor branches' number was significantly correlated with erectile function. The sub-analysis of the number of nNOS positive DPN minor branches also matched with the time course of the erectile function after BCNI. We suggest the regeneration of the DPNs minor branches would ameliorate the erectile function in BCNI rats.

原文英語
文章編號18988
期刊Scientific Reports
8
發行號1
DOIs
出版狀態已發佈 - 十二月 1 2018

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    Chen, Y. L., Chao, T. T., Wu, Y. N., Chen, M. C., Lin, Y. H., Liao, C. H., Wu, C. C., Chen, K. C., Chou, S. S. P., & Chiang, H. S. (2018). NNOS-positive minor-branches of the dorsal penile nerves is associated with erectile function in the bilateral cavernous injury model of rats. Scientific Reports, 8(1), [18988]. https://doi.org/10.1038/s41598-017-18988-2