NMDA inhibits oxotremorine-induced acid secretion via the NO-dependent cyclic GMP system in rat stomach

L. H. Tsai, Y. J. Lee

研究成果: 雜誌貢獻文章

6 引文 斯高帕斯(Scopus)

摘要

The mechanism of N-methyl-D-aspartate (NMDA) inhibits oxotremorine-induced acid secretion was examined in rat stomach, in relation to the cyclic GMP system. NMDA (10 -7 M) did not affect the spontaneous acid secretion from the everted preparations of isolated rat stomach, but inhibited the acid secretion stimulated by oxotremorine, and this effect of NMDA was antagonized by 2-amino-5-phosphonovaleric acid (AP-5), (±)3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP) or N G-nitro-L-arginine (L-NNA). NMDA also elevated the cyclic GMP content of mucosal slices from rat stomach, and this effect of NMDA was antagonized by L-NNA. These results indicate that NMDA receptors are present in the rat stomach and regulate the gastric acid secretion. The mechanism underlying the effect of NMDA inhibits oxotremorine-induced acid secretion may be mediated by the NO-dependent cyclic GMP system.
原文英語
頁(從 - 到)193-198
頁數6
期刊Chinese Journal of Physiology
44
發行號4
出版狀態已發佈 - 2001

    指紋

ASJC Scopus subject areas

  • Physiology

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