摘要

The nitro group is considered to be a versatile and unique functional group in medicinal chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues and is often categorized as a structural alert or a toxicophore, and evidence related to drugs containing nitro groups is rather contradictory. In general, drugs containing nitro groups have been extensively associated with mutagenicity and genotoxicity. In this context, efforts towards the structure-mutagenicity or structure-genotoxicity relationships have been undertaken. The current perspective covers various aspects of agents that contain nitro groups, their bioreductive activation mechanisms, and their toxicities, and approaches to combat their toxicity issues. In addition, recent advances in the field of anticancer, antitubercular and antiparasitic agents containing nitro groups, along with a patent survey on hypoxia-activated prodrugs containing nitro groups, are also covered.
原文英語
頁(從 - 到)2851-2893
頁數43
期刊Journal of Medicinal Chemistry
62
發行號6
DOIs
出版狀態已發佈 - 三月 28 2019

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

指紋 深入研究「Nitro-Group-Containing Drugs」主題。共同形成了獨特的指紋。

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