Newly Diagnosed Anemia Increases Risk of Parkinson's disease: A Population-Based Cohort Study

Chien-Tai Hung, Yao Hsien Huang, Hung Yi Liu, Hung Yi Chiou, Lung Chan, Li Nien Chien

研究成果: 雜誌貢獻文章

7 引文 (Scopus)

摘要

Anemia and low hemoglobin have been identified to increase Parkinson's disease (PD) risk. This population-based cohort study investigated PD risk in newly diagnosed anemic patients by using data from the Taiwan National Health Insurance Research Database. All newly diagnosed anemic patients (n = 86,334) without a history of stroke, neurodegenerative diseases, traumatic brain injury, major operations, or blood loss diseases were enrolled. A cohort of nonanemic controls, 1:1 matched with anemic patients on the basis of the demographics and pre-existing medical conditions, was also included. Competing risk analysis was used to evaluate PD risk in anemic patients compared with that in their matched controls. The adjusted hazard ratio (aHR) of PD risk in the anemic patients was 1.36 (95% confidence interval [CI]: 1.22-1.52, p < 0.001). Iron deficiency anemia (IDA) patients tended to exhibit a higher PD risk (aHR: 1.49; 95% CI: 1.24-1.79, p < 0.001). Furthermore, Iron supplement did not significantly affect the PD risk: the aHRs for PD risk were 1.32 (95% CI: 1.07-1.63, p < 0.01) and 1.86 (95% CI: 1.46-2.35, p < 0.001) in IDA patients with and without iron supplementation, respectively. The population-based cohort study indicated newly diagnosed anemia increases PD risk.
原文英語
文章編號29651
期刊Scientific Reports
6
DOIs
出版狀態已發佈 - 七月 14 2016

指紋

Parkinson Disease
Anemia
Cohort Studies
Population
Confidence Intervals
Iron-Deficiency Anemias
Iron
Preexisting Condition Coverage
Hematologic Diseases
National Health Programs
Taiwan
Neurodegenerative Diseases
Hemoglobins
Stroke
Demography
Databases
Research

ASJC Scopus subject areas

  • General

引用此文

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title = "Newly Diagnosed Anemia Increases Risk of Parkinson's disease: A Population-Based Cohort Study",
abstract = "Anemia and low hemoglobin have been identified to increase Parkinson's disease (PD) risk. This population-based cohort study investigated PD risk in newly diagnosed anemic patients by using data from the Taiwan National Health Insurance Research Database. All newly diagnosed anemic patients (n = 86,334) without a history of stroke, neurodegenerative diseases, traumatic brain injury, major operations, or blood loss diseases were enrolled. A cohort of nonanemic controls, 1:1 matched with anemic patients on the basis of the demographics and pre-existing medical conditions, was also included. Competing risk analysis was used to evaluate PD risk in anemic patients compared with that in their matched controls. The adjusted hazard ratio (aHR) of PD risk in the anemic patients was 1.36 (95{\%} confidence interval [CI]: 1.22-1.52, p < 0.001). Iron deficiency anemia (IDA) patients tended to exhibit a higher PD risk (aHR: 1.49; 95{\%} CI: 1.24-1.79, p < 0.001). Furthermore, Iron supplement did not significantly affect the PD risk: the aHRs for PD risk were 1.32 (95{\%} CI: 1.07-1.63, p < 0.01) and 1.86 (95{\%} CI: 1.46-2.35, p < 0.001) in IDA patients with and without iron supplementation, respectively. The population-based cohort study indicated newly diagnosed anemia increases PD risk.",
author = "Chien-Tai Hung and Huang, {Yao Hsien} and Liu, {Hung Yi} and Chiou, {Hung Yi} and Lung Chan and Chien, {Li Nien}",
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