Abstract Purpose: To evaluate the relationship of newly defined lens position parameters with intraocular pressure (IOP) reduction after cataract surgery in non-glaucomatous eyes. Methods: In this prospective study, non-glaucomatous eyes which underwent phacoemulsification cataract surgery were included. IOP was measured preoperatively and 1.5 months after surgery. Change in IOP and its relation to newly defined lens biometric parameters, which were assessed using parameters from LENSTAR LS 900 (Haag-Streit, Inc., Koeniz, Switzerland) preoperatively, including adjusted lens position (aLP; defined as aqueous depth [AD; defined as distance from corneal endothelium to the anterior lens surface] +1/2 lens thickness ) and adjusted relative lens position (aRLP; defined as aLP/axial length [AXL]) were evaluated. In addition, preoperative IOP, previous laser peripheral iridotomy, lens thickness, AXL, AD, and anterior chamber depth were assessed as predictors. The main outcome measure was IOP change after cataract surgery. Results: Among the 62 consecutively enrolled patients (24 male, 38 female), 62 eyes were included in the analysis (if both eyes eligible, right eye selected) and the overall mean age was 72.8 ±9.0 years. The average IOP reduction was 2.62±2.3 mmHg, from a preoperative mean of 15.16 ±3.36 mmHg, at 1.5 months after cataract surgery. After adjusting for age, gender, and pre-operative IOP, the amount of IOP reduction was significantly greater in more anteriorly positioned lenses; aLP (p= 0.042) and aRLP (p= 0.022) both showed statistically significant correlation with IOP reduction. In multivariate linear regression analysis, higher preoperative IOP was significantly associated with IOP decrease (p < 0.001); shallower ACD (p= 0.09) and smaller AD (p= 0.088) showed moderate, but not statistically significant association. Conclusions: The amount of IOP reduction after cataract surgery in non-glaucomatous eyes is significantly greater in more anteriorly positioned lenses. Future studies will show whether similar relationships exist in glaucomatous eyes undergoing cataract surgery.
|頁（從 - 到）||4992|
|期刊||Investigative Ophthalmology and Visual Science|
|出版狀態||已發佈 - 六月 11 2015|