New use for old drugs: The protective effect of risperidone on colorectal cancer

Vincent Chin Hung Chen, Yi Hsuan Hsieh, Tzu Chin Lin, Mong Liang Lu, Yin To Liao, Yao Hsu Yang, Tsai Ching Hsu, Robert Stewart, Jun Cheng Weng, Min Jing Lee, Wei Che Chiu, Bor Show Tzang

研究成果: 雜誌貢獻文章

摘要

Background: The potential of old drugs in novel indications is being greatly valued. We propose a triple-model study involving population-based, cell, and animal studies to investigate the effects of risperidone, a type of second-generation antipsychotic (SGA) drug, on colorectal cancer. Methods: We used data from Taiwan’s National Health Insurance Research Database between 1997 and 2013 to compare 101,989 patients with colorectal cancer and 101,989 controls. Conditional logistic regression analyses were used to explore the association between SGA exposure and the risk of colorectal cancer. The following bench studies were performed to evaluate the findings of the population-based study. Results: We found that SGAs had been less commonly used in colorectal cancer patients than in controls. The colorectal cancer risk was reduced with an increase in the cumulative defined daily dose (cDDD) of SGAs. The adjusted odds ratio of antipsychotic use for cDDD days was 0.32 (95% CI: 0.25–0.42). Risperidone exhibited the most prominent tumor inhibition effect in a cell screen study. Bench data revealed that risperidone significantly induced apoptosis and elevated intracellular ROS in human SW480 cells and suppressed the proliferation of the xenografted SW480 tumor in nude mice. Conclusion: This triple-model study demonstrates the association between risperidone usage and a lower risk of colorectal cancer.

原文英語
文章編號1560
頁(從 - 到)1-16
頁數16
期刊Cancers
12
發行號6
DOIs
出版狀態已發佈 - 六月 2020

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Chen, V. C. H., Hsieh, Y. H., Lin, T. C., Lu, M. L., Liao, Y. T., Yang, Y. H., Hsu, T. C., Stewart, R., Weng, J. C., Lee, M. J., Chiu, W. C., & Tzang, B. S. (2020). New use for old drugs: The protective effect of risperidone on colorectal cancer. Cancers, 12(6), 1-16. [1560]. https://doi.org/10.3390/cancers12061560