New use for old drugs

The protective effect of atypical antipsychotics on hepatocellular carcinoma

Vincent Chin Hung Chen, Hsiang Lin Chan, Tsai Ching Hsu, Mong Liang Lu, Yi Chen Lee, Yena Lee, Jing Yi Siow, Roger S. McIntyre, Aileen J. Zhou, Bor Show Tzang, Charles Tzu Chi Lee

研究成果: 雜誌貢獻文章

摘要

It has been encouraged to use large existing data like insurance claims data to investigate the new indications of old drugs. New strategies of research are warranted to identify feasible drugs. We conducted a dual research model with a population-based case–control study using Taiwan's National Health Insurance Research Database and an in vitro study to investigate the association between atypical antipsychotic and Hepatocellular carcinoma (HCC) risk. The study herein consists of two components. The first is a population-based case–control study using existing data from the Taiwan National Health Insurance Research Database. The second component was an in vitro study in which HCC cell lines (Huh7 and Hep G2) were treated with risperidone, quetiapine and clozapine. after treatment of the foregoing antipsychotics, the HCC cell lines were assessed for cell proliferation, invasion and apoptosis. Multivariate conditional logistic regression analysis revealed that antipsychotic use was independently and inversely associated with HCC risk (adjusted odds-ratio [aOR]:0.85, 95% CI: 0.81–0.89). The protective effect was dose-dependent: compared to the low cumulative defined daily dose (cDDD) group (0–29 cDDD), the 30–89 cDDD and ≥ 90 cDDD groups were associated with significantly reduced risk for HCC (aOR: 0.56, 95% CI: 0.41–0.76; aOR: 0.37, 95% CI: 0.27–0.50, respectively). In vitro study results indicated that risperidone, quetiapine and clozapine significantly inhibited cell proliferation, invasion and induced apoptosis in human HCC cell lines. Our results herein suggested that antipsychotic use might reduce the risk of HCC and may provide evidence for new uses of old drugs.
原文英語
期刊International Journal of Cancer
DOIs
出版狀態已發佈 - 2019

指紋

Protective Agents
Antipsychotic Agents
Hepatocellular Carcinoma
Risperidone
Clozapine
Odds Ratio
National Health Programs
Taiwan
Research
Cell Proliferation
Pharmaceutical Preparations
Databases
Apoptosis
Cell Line
Hep G2 Cells
Insurance
Population
Logistic Models
Regression Analysis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

引用此文

New use for old drugs : The protective effect of atypical antipsychotics on hepatocellular carcinoma. / Chen, Vincent Chin Hung; Chan, Hsiang Lin; Hsu, Tsai Ching; Lu, Mong Liang; Lee, Yi Chen; Lee, Yena; Siow, Jing Yi; McIntyre, Roger S.; Zhou, Aileen J.; Tzang, Bor Show; Lee, Charles Tzu Chi.

於: International Journal of Cancer, 2019.

研究成果: 雜誌貢獻文章

Chen, VCH, Chan, HL, Hsu, TC, Lu, ML, Lee, YC, Lee, Y, Siow, JY, McIntyre, RS, Zhou, AJ, Tzang, BS & Lee, CTC 2019, 'New use for old drugs: The protective effect of atypical antipsychotics on hepatocellular carcinoma', International Journal of Cancer. https://doi.org/10.1002/ijc.31980
Chen, Vincent Chin Hung ; Chan, Hsiang Lin ; Hsu, Tsai Ching ; Lu, Mong Liang ; Lee, Yi Chen ; Lee, Yena ; Siow, Jing Yi ; McIntyre, Roger S. ; Zhou, Aileen J. ; Tzang, Bor Show ; Lee, Charles Tzu Chi. / New use for old drugs : The protective effect of atypical antipsychotics on hepatocellular carcinoma. 於: International Journal of Cancer. 2019.
@article{8e6dbf57535f4d18b61a8f630441c0a4,
title = "New use for old drugs: The protective effect of atypical antipsychotics on hepatocellular carcinoma",
abstract = "It has been encouraged to use large existing data like insurance claims data to investigate the new indications of old drugs. New strategies of research are warranted to identify feasible drugs. We conducted a dual research model with a population-based case–control study using Taiwan's National Health Insurance Research Database and an in vitro study to investigate the association between atypical antipsychotic and Hepatocellular carcinoma (HCC) risk. The study herein consists of two components. The first is a population-based case–control study using existing data from the Taiwan National Health Insurance Research Database. The second component was an in vitro study in which HCC cell lines (Huh7 and Hep G2) were treated with risperidone, quetiapine and clozapine. after treatment of the foregoing antipsychotics, the HCC cell lines were assessed for cell proliferation, invasion and apoptosis. Multivariate conditional logistic regression analysis revealed that antipsychotic use was independently and inversely associated with HCC risk (adjusted odds-ratio [aOR]:0.85, 95{\%} CI: 0.81–0.89). The protective effect was dose-dependent: compared to the low cumulative defined daily dose (cDDD) group (0–29 cDDD), the 30–89 cDDD and ≥ 90 cDDD groups were associated with significantly reduced risk for HCC (aOR: 0.56, 95{\%} CI: 0.41–0.76; aOR: 0.37, 95{\%} CI: 0.27–0.50, respectively). In vitro study results indicated that risperidone, quetiapine and clozapine significantly inhibited cell proliferation, invasion and induced apoptosis in human HCC cell lines. Our results herein suggested that antipsychotic use might reduce the risk of HCC and may provide evidence for new uses of old drugs.",
keywords = "antipsychotic, hepatocellular carcinoma, in vitro study, population-based case–control study",
author = "Chen, {Vincent Chin Hung} and Chan, {Hsiang Lin} and Hsu, {Tsai Ching} and Lu, {Mong Liang} and Lee, {Yi Chen} and Yena Lee and Siow, {Jing Yi} and McIntyre, {Roger S.} and Zhou, {Aileen J.} and Tzang, {Bor Show} and Lee, {Charles Tzu Chi}",
year = "2019",
doi = "10.1002/ijc.31980",
language = "English",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",

}

TY - JOUR

T1 - New use for old drugs

T2 - The protective effect of atypical antipsychotics on hepatocellular carcinoma

AU - Chen, Vincent Chin Hung

AU - Chan, Hsiang Lin

AU - Hsu, Tsai Ching

AU - Lu, Mong Liang

AU - Lee, Yi Chen

AU - Lee, Yena

AU - Siow, Jing Yi

AU - McIntyre, Roger S.

AU - Zhou, Aileen J.

AU - Tzang, Bor Show

AU - Lee, Charles Tzu Chi

PY - 2019

Y1 - 2019

N2 - It has been encouraged to use large existing data like insurance claims data to investigate the new indications of old drugs. New strategies of research are warranted to identify feasible drugs. We conducted a dual research model with a population-based case–control study using Taiwan's National Health Insurance Research Database and an in vitro study to investigate the association between atypical antipsychotic and Hepatocellular carcinoma (HCC) risk. The study herein consists of two components. The first is a population-based case–control study using existing data from the Taiwan National Health Insurance Research Database. The second component was an in vitro study in which HCC cell lines (Huh7 and Hep G2) were treated with risperidone, quetiapine and clozapine. after treatment of the foregoing antipsychotics, the HCC cell lines were assessed for cell proliferation, invasion and apoptosis. Multivariate conditional logistic regression analysis revealed that antipsychotic use was independently and inversely associated with HCC risk (adjusted odds-ratio [aOR]:0.85, 95% CI: 0.81–0.89). The protective effect was dose-dependent: compared to the low cumulative defined daily dose (cDDD) group (0–29 cDDD), the 30–89 cDDD and ≥ 90 cDDD groups were associated with significantly reduced risk for HCC (aOR: 0.56, 95% CI: 0.41–0.76; aOR: 0.37, 95% CI: 0.27–0.50, respectively). In vitro study results indicated that risperidone, quetiapine and clozapine significantly inhibited cell proliferation, invasion and induced apoptosis in human HCC cell lines. Our results herein suggested that antipsychotic use might reduce the risk of HCC and may provide evidence for new uses of old drugs.

AB - It has been encouraged to use large existing data like insurance claims data to investigate the new indications of old drugs. New strategies of research are warranted to identify feasible drugs. We conducted a dual research model with a population-based case–control study using Taiwan's National Health Insurance Research Database and an in vitro study to investigate the association between atypical antipsychotic and Hepatocellular carcinoma (HCC) risk. The study herein consists of two components. The first is a population-based case–control study using existing data from the Taiwan National Health Insurance Research Database. The second component was an in vitro study in which HCC cell lines (Huh7 and Hep G2) were treated with risperidone, quetiapine and clozapine. after treatment of the foregoing antipsychotics, the HCC cell lines were assessed for cell proliferation, invasion and apoptosis. Multivariate conditional logistic regression analysis revealed that antipsychotic use was independently and inversely associated with HCC risk (adjusted odds-ratio [aOR]:0.85, 95% CI: 0.81–0.89). The protective effect was dose-dependent: compared to the low cumulative defined daily dose (cDDD) group (0–29 cDDD), the 30–89 cDDD and ≥ 90 cDDD groups were associated with significantly reduced risk for HCC (aOR: 0.56, 95% CI: 0.41–0.76; aOR: 0.37, 95% CI: 0.27–0.50, respectively). In vitro study results indicated that risperidone, quetiapine and clozapine significantly inhibited cell proliferation, invasion and induced apoptosis in human HCC cell lines. Our results herein suggested that antipsychotic use might reduce the risk of HCC and may provide evidence for new uses of old drugs.

KW - antipsychotic

KW - hepatocellular carcinoma

KW - in vitro study

KW - population-based case–control study

UR - http://www.scopus.com/inward/record.url?scp=85058996770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058996770&partnerID=8YFLogxK

U2 - 10.1002/ijc.31980

DO - 10.1002/ijc.31980

M3 - Article

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

ER -