New Trichothecenes Isolated from the Marine Algicolous Fungus Trichoderma brevicompactum

Safwan Safwan, Shih Wei Wang, George Hsiao, Sui Wen Hsiao, Su Jung Hsu, Tzong Huei Lee, Ching Kuo Lee

研究成果: 雜誌貢獻文章同行評審

摘要

Eight trichothecenes, including four new compounds 1–4 and four known entities 5–8, together with one known cyclonerane (9) were isolated from the solid-state fermentation of Trichoderma brevicompactum NTU439 isolated from the marine alga Mastophora rosea. The structures of 1–9 were determined by 1D/2D NMR (nuclear magnetic resonance), MS (mass spectrometry), and IR (infrared spectroscopy) spectroscopic data. All of the compounds were evaluated for cytotoxic activity against HCT-116, PC-3, and SK-Hep-1 cancer cells by the SRB assay, and compound 8 showed promising cytotoxic activity against all three cancer cell lines with the IC50 values of 3.3 ± 0.3, 5.3 ± 0.3, and 1.8 ± 0.8 µM, respectively. Compounds 1–2, 4–6, and 7–8 potently inhibited LPS-induced NO production, and compounds 5 and 8 showed markedly inhibited gelatinolysis of MMP-9 in S1 protein-stimulated THP-1 monocytes.

原文英語
文章編號80
期刊Marine Drugs
20
發行號2
DOIs
出版狀態已發佈 - 2月 2022

ASJC Scopus subject areas

  • 藥物發現

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