New isoflavones and anti-inflammatory constituents from the fruits of Cnidium monnieri

Zong-Huei Li, Yuan Chih Chen, Tsong Long Hwang, Chih Wen Shu, Ping Jyun Sung, Yun Ping Lim, Wen Lung Kuo, Jih Jung Chen

研究成果: 雜誌貢獻文章同行評審

12 引文 斯高帕斯(Scopus)

摘要

The fruit of Cnidium monnieri is commercially used as healthcare products for the improvement of impotence and skin diseases. Three new coumarins, 3'-O-methylmurraol (1), rel-(1'S,2'S)-1'-O-methylphlojodicarpin (2), and (1'S,2'S)-1'-O-methylvaginol (3), have been isolated from the fruits of C. monnieri, together with 14 known compounds (4-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 1, 4-12, and 14-17 exhibited inhibition (IC50 ≤ 7.31 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 7, 9-11, 15, and 17 inhibited fMLP/CB-induced elastase release with IC50 values ≤7.83 μg/mL. This investigation reveals that bioactive isolates (especially 6, 7, 14, and 17) could be further developed as potential candidates for the treatment or prevention of various inflammatory diseases.
原文英語
頁(從 - 到)9566-9578
頁數13
期刊International Journal of Molecular Sciences
15
發行號6
DOIs
出版狀態已發佈 - 3月 28 2014

ASJC Scopus subject areas

  • 物理與理論化學
  • 有機化學
  • 光譜
  • 無機化學
  • 催化
  • 分子生物學
  • 電腦科學應用
  • 醫藥 (全部)

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