@article{c3349498738b4d77ab000f1fabc492f5,
title = "New Hirsutinolide-Type Sesquiterpenoids from Vernonia cinerea Inhibit Nitric Oxide Production in LPS-Stimulated RAW264.7 Cells",
abstract = "Phytochemical investigation of ethanol extracts from two Taiwanese collections of Vernonia cinerea resulted in the isolation of eighteen hirsutinolide-type sesquiterpenoids, including seven new ones designated as vernolides E – K ( 1 – 7 ). All structures were determined by a combination of detailed spectroscopic analyses (NMR and MS) and comparison with reported data. In an in vitro anti-inflammatory assay, compounds 3, 7, 9, 11 , and 14 exhibited strong inhibitory activities toward NO production by LPS-induced RAW264.7 macrophages, with IC 50 values of 1.18, 0.85, 0.66, 0.71 and 0.45 µM, respectively, without affecting cellular viability at 40 µM. Preliminary structure-activity relationships indicate that the ester groups at C-8 and C-13 may enhance inhibition of NO production. ",
keywords = "anti-inflammatory, Asteraceae, hirsutinolide, nitric oxide, RAW264.7 cells, vernolide, Vernonia cinerea",
author = "Kuo, {Li Ming Yang} and Tseng, {Pei Yi} and Lin, {Yu Chi} and Liaw, {Chia Ching} and Zhang, {Li Jie} and Tsai, {Keng Chang} and Lin, {Zhi Hu} and Ho, {Hsiu O.} and Kuo, {Yao Haur}",
note = "Funding Information: This work was supported by grants from the National Science Council (NSC098-2811-B‑077-002 and NSC98-2320-B-077-005-MY3) and Ministry of Science and Technology (MOST104-2320-B‑077-006-MY3), as well as from the Ministry of Health and Welfare (MM10601-0160). Publisher Copyright: {\textcopyright} Georg Thieme Verlag KG Stuttgart. New York. Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",
year = "2018",
month = jul,
day = "9",
doi = "10.1055/a-0647-1901",
language = "English",
volume = "84",
pages = "1348--1354",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "18",
}