New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp.

Jyh Horng Sheu, Ping Jyun Sung, Li Huei Huang, Shu Fang Lee, Tzuhua Wu, Bih Yuan Chang, Chang Yih Duh, Lee Shing Fang, Keryea Soong, Tsong Jen Lee

研究成果: 雜誌貢獻文章

59 引文 斯高帕斯(Scopus)

摘要

Three new briaran diterpenes, 2β-acetoxy-2-(debutyryloxy)stecholide E (3), 9-deacetylstylatulide lactone (4), and 4β-acetoxy-9-deacetylstylatulide lactone (5), and two known diterpenes, brianthein W (1) and 9- deacetylbriareolide H (2), have been isolated from a Briareum sp. of gorgonian. The structures and relative stereochemistry of these compounds were determined by spectroscopic and chemical methods. Diterpenes 2-4 and the corresponding 9-acetyl derivatives 6, 7, and 12 exhibited cytotoxicity toward various cancer cell lines.
原文英語
頁(從 - 到)935-938
頁數4
期刊Journal of Natural Products
59
發行號10
DOIs
出版狀態已發佈 - 十月 1 1996

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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  • 引用此

    Sheu, J. H., Sung, P. J., Huang, L. H., Lee, S. F., Wu, T., Chang, B. Y., Duh, C. Y., Fang, L. S., Soong, K., & Lee, T. J. (1996). New cytotoxic briaran diterpenes from the formosan gorgonian Briareum sp. Journal of Natural Products, 59(10), 935-938. https://doi.org/10.1021/np960218s