Two new abietane-type diterpenoids, 15-hydroxy-12-O-methylsugiol (1) and 2?-hydroxy-12-O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM.
ASJC Scopus subject areas
- Drug Discovery
- Plant Science
- Complementary and alternative medicine