Neuroprotective properties of nitric oxide and S-nitrosoglutathione

Pekka Rauhala, Tsugunobu Andoh, Juang-Ching Chiue

研究成果: 雜誌貢獻文章同行評審

38 引文 斯高帕斯(Scopus)


Oxidative stress and apoptosis may play an important role in the neurodegeneration. The present paper outlines antioxidative and antiapototic mechanisms of nitric oxide and S-nitrosothiols, which could mediate neuroprotection. Nitric oxide generated by nitric oxide synthase or released from an endogenous S-nitrosothiol, S-nitrosoglutathione may up-regulate antioxidative thioredoxin system and antiapototic Bcl-2 protein through a cGMP-dependent mechanism. Moreover, nitric oxide radicals have been shown to have direct antioxidant effect through their reaction with free radicals and iron-oxygen complexes. In addition to serving as a stabilizer and carrier of nitric oxide, S-nitrosoglutathione may have protective effect through transnitrosylation reactions. Based on these new findings, a hypothesis arises that the homeostasis of nitric oxide, S-nitrosothiols, glutathione, and thioredoxin systems is important for protection against oxidative stress, apoptosis, and related neurodegenerative disorders.
期刊Toxicology and Applied Pharmacology
發行號2 SUPPL.
出版狀態已發佈 - 9月 1 2005

ASJC Scopus subject areas

  • 藥理
  • 毒理學


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