Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: A neuroimaging and neurotrophin study

Nai Fang Chi, Ho Ling Liu, Jen Tsung Yang, Jr Rung Lin, Shu Li Liao, Bo Han Peng, Yen Tung Lee, Tsong Hai Lee

研究成果: 雜誌貢獻文章

4 引文 斯高帕斯(Scopus)

摘要

BNG-1 is a herb complex used in traditional Chinese medicine to treat stroke. In this study, we attempted to identify the neuroprotective mechanism of BNG-1 by using neuroimaging and neurotrophin analyses of a stroke animal model. Rats were treated with either saline or BNG-1 for 7 d after 60-min middle cerebral artery occlusion by filament model. The temporal change of magnetic resonance (MR) imaging of brain was studied using a 7 Tesla MR imaging (MRI) system and the temporal expressions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) in brain were analyzed before operation and at 4 h, 2 d, and 7 d after operation. Compared with the saline group, the BNG-1 group exhibited a smaller infarction volume in the cerebral cortex in T2 image from as early as 4 h to 7 d, less edema in the cortex in diffusion weighted image from 2 to 7 d, earlier reduction of postischemic hyperperfusion in both the cortex and striatum in perfusion image at 4 h, and earlier normalization of the ischemic pattern in the striatum in susceptibility weighted image at 2 d. NT-3 and BDNF levels were higher in the BNG-1 group than the saline group at 7 d. We concluded that the protective effect of BNG-1 against cerebral ischemic injury might act through improving cerebral hemodynamics and recovering neurotrophin generation.

原文英語
文章編號e114909
期刊PLoS One
9
發行號12
DOIs
出版狀態已發佈 - 十二月 15 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

指紋 深入研究「Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: A neuroimaging and neurotrophin study」主題。共同形成了獨特的指紋。

  • 引用此

    Chi, N. F., Liu, H. L., Yang, J. T., Lin, J. R., Liao, S. L., Peng, B. H., Lee, Y. T., & Lee, T. H. (2014). Neuroprotective mechanism of BNG-1 against focal cerebral ischemia: A neuroimaging and neurotrophin study. PLoS One, 9(12), [e114909]. https://doi.org/10.1371/journal.pone.0114909