摘要
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 1174-1181 |
| 頁數 | 8 |
| 期刊 | Magnetic Resonance Imaging |
| 卷 | 31 |
| 發行號 | 7 |
| DOIs | |
| 出版狀態 | 已發佈 - 九月 2013 |
指紋
ASJC Scopus subject areas
- Biophysics
- Radiology Nuclear Medicine and imaging
- Biomedical Engineering
引用此文
Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation. / Huang, Y. C.; Tzeng, W. S.; Wang, C. C.; Cheng, B. C.; Chang, Y. K.; Chen, H. H.; Lin, P. C.; Huang, T. Y.; Chuang, T. J.; Lin, J. W.; Chang, C. P.
於: Magnetic Resonance Imaging, 卷 31, 編號 7, 09.2013, p. 1174-1181.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Neuroprotective effect of agmatine in rats with transient cerebral ischemia using MR imaging and histopathologic evaluation
AU - Huang, Y. C.
AU - Tzeng, W. S.
AU - Wang, C. C.
AU - Cheng, B. C.
AU - Chang, Y. K.
AU - Chen, H. H.
AU - Lin, P. C.
AU - Huang, T. Y.
AU - Chuang, T. J.
AU - Lin, J. W.
AU - Chang, C. P.
PY - 2013/9
Y1 - 2013/9
N2 - Purpose: This study aimed to further investigate the effects of agmatine on brain edema in the rats with middle cerebral artery occlusion (MCAO) injury using magnetic resonance imaging (MRI) monitoring and biochemical and histopathologic evaluation. Materials and methods: Following surgical induction of MCAO for 90. min, agmatine was injected 5. min after beginning of reperfusion and again once daily for the next 3 post-operative days. The events during ischemia and reperfusion were investigated by T2-weighted images (T2WI), serial diffusion-weighted images (DWI), calculated apparent diffusion coefficient (ADC) maps and contrast-enhanced T1-weighted images (CE-T1WI) during 3. h-72. h in a 1.5. T Siemens MAGNETON Avanto Scanner. Lesion volumes were analyzed in a blinded and randomized manner. Triphenyltetrazolium chloride (TTC), Nissl, and Evans Blue stainings were performed at the corresponding sections. Results: Increased lesion volumes derived from T2WI, DWI, ADC, CE-T1WI, and TTC all were noted at 3. h and peaked at 24. h-48. h after MCAO injury. TTC-derived infarct volumes were not significantly different from the T2WI, DWI-, and CE-T1WI-derived lesion volumes at the last imaging time (72. h) point except for significantly smaller ADC lesions in the MCAO model (P.
AB - Purpose: This study aimed to further investigate the effects of agmatine on brain edema in the rats with middle cerebral artery occlusion (MCAO) injury using magnetic resonance imaging (MRI) monitoring and biochemical and histopathologic evaluation. Materials and methods: Following surgical induction of MCAO for 90. min, agmatine was injected 5. min after beginning of reperfusion and again once daily for the next 3 post-operative days. The events during ischemia and reperfusion were investigated by T2-weighted images (T2WI), serial diffusion-weighted images (DWI), calculated apparent diffusion coefficient (ADC) maps and contrast-enhanced T1-weighted images (CE-T1WI) during 3. h-72. h in a 1.5. T Siemens MAGNETON Avanto Scanner. Lesion volumes were analyzed in a blinded and randomized manner. Triphenyltetrazolium chloride (TTC), Nissl, and Evans Blue stainings were performed at the corresponding sections. Results: Increased lesion volumes derived from T2WI, DWI, ADC, CE-T1WI, and TTC all were noted at 3. h and peaked at 24. h-48. h after MCAO injury. TTC-derived infarct volumes were not significantly different from the T2WI, DWI-, and CE-T1WI-derived lesion volumes at the last imaging time (72. h) point except for significantly smaller ADC lesions in the MCAO model (P.
KW - Agmatine
KW - Brain edema
KW - Magnetic resonance image
KW - Pharmacology
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=84880731514&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880731514&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2013.03.026
DO - 10.1016/j.mri.2013.03.026
M3 - Article
C2 - 23642800
AN - SCOPUS:84880731514
VL - 31
SP - 1174
EP - 1181
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 7
ER -