摘要
Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.
| 原文 | 英語 |
|---|---|
| 頁（從 - 到） | 10-17 |
| 頁數 | 8 |
| 期刊 | European Psychiatry |
| 卷 | 55 |
| DOIs | |
| 出版狀態 | 已發佈 - 一月 1 2019 |
| 對外發佈 | Yes |
指紋
ASJC Scopus subject areas
- Psychiatry and Mental health
引用此文
Neuronal variability of Resting State activity in Eating Disorders : increase and decoupling in Ventral Attention Network and relation with clinical symptoms. / Spalatro, Angela V.; Amianto, Federico; Huang, Zirui; D'Agata, Federico; Bergui, Mauro; Abbate Daga, Giovanni; Fassino, Secondo; Northoff, Georg.
於: European Psychiatry, 卷 55, 01.01.2019, p. 10-17.研究成果: 雜誌貢獻 › 文章
}
TY - JOUR
T1 - Neuronal variability of Resting State activity in Eating Disorders
T2 - increase and decoupling in Ventral Attention Network and relation with clinical symptoms
AU - Spalatro, Angela V.
AU - Amianto, Federico
AU - Huang, Zirui
AU - D'Agata, Federico
AU - Bergui, Mauro
AU - Abbate Daga, Giovanni
AU - Fassino, Secondo
AU - Northoff, Georg
N1 - Crown Copyright © 2018. Published by Elsevier Masson SAS. All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.
AB - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.
KW - Eating Disorders
KW - Inhibitory control
KW - Interoceptive awareness
KW - Neuronal variability
KW - Ventral Attention Network
KW - Interoception/physiology
KW - Brain Mapping/methods
KW - Humans
KW - Magnetic Resonance Imaging/methods
KW - Psychometrics/methods
KW - Feeding and Eating Disorders/physiopathology
KW - Ventral Thalamic Nuclei/diagnostic imaging
KW - Neuronal Plasticity/physiology
KW - Adult
KW - Female
KW - Psychopathology
KW - Attention/physiology
KW - Inhibition (Psychology)
UR - http://www.scopus.com/inward/record.url?scp=85055546625&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055546625&partnerID=8YFLogxK
U2 - 10.1016/j.eurpsy.2018.08.005
DO - 10.1016/j.eurpsy.2018.08.005
M3 - Article
VL - 55
SP - 10
EP - 17
JO - European Psychiatry
JF - European Psychiatry
SN - 0924-9338
ER -