Neuronal variability of Resting State activity in Eating Disorders

increase and decoupling in Ventral Attention Network and relation with clinical symptoms

Angela V. Spalatro, Federico Amianto, Zirui Huang, Federico D'Agata, Mauro Bergui, Giovanni Abbate Daga, Secondo Fassino, Georg Northoff

研究成果: 雜誌貢獻文章

2 引文 (Scopus)

摘要

Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

原文英語
頁(從 - 到)10-17
頁數8
期刊European Psychiatry
55
DOIs
出版狀態已發佈 - 一月 1 2019
對外發佈Yes

指紋

Appetite Depressants
Bulimia Nervosa
Anorexia Nervosa
Psychometrics
Feeding and Eating Disorders
Biomarkers
Magnetic Resonance Imaging
Oxygen
Therapeutics

ASJC Scopus subject areas

  • Psychiatry and Mental health

引用此文

Neuronal variability of Resting State activity in Eating Disorders : increase and decoupling in Ventral Attention Network and relation with clinical symptoms. / Spalatro, Angela V.; Amianto, Federico; Huang, Zirui; D'Agata, Federico; Bergui, Mauro; Abbate Daga, Giovanni; Fassino, Secondo; Northoff, Georg.

於: European Psychiatry, 卷 55, 01.01.2019, p. 10-17.

研究成果: 雜誌貢獻文章

Spalatro, Angela V. ; Amianto, Federico ; Huang, Zirui ; D'Agata, Federico ; Bergui, Mauro ; Abbate Daga, Giovanni ; Fassino, Secondo ; Northoff, Georg. / Neuronal variability of Resting State activity in Eating Disorders : increase and decoupling in Ventral Attention Network and relation with clinical symptoms. 於: European Psychiatry. 2019 ; 卷 55. 頁 10-17.
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title = "Neuronal variability of Resting State activity in Eating Disorders: increase and decoupling in Ventral Attention Network and relation with clinical symptoms",
abstract = "Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.",
keywords = "Eating Disorders, Inhibitory control, Interoceptive awareness, Neuronal variability, Ventral Attention Network, Interoception/physiology, Brain Mapping/methods, Humans, Magnetic Resonance Imaging/methods, Psychometrics/methods, Feeding and Eating Disorders/physiopathology, Ventral Thalamic Nuclei/diagnostic imaging, Neuronal Plasticity/physiology, Adult, Female, Psychopathology, Attention/physiology, Inhibition (Psychology)",
author = "Spalatro, {Angela V.} and Federico Amianto and Zirui Huang and Federico D'Agata and Mauro Bergui and {Abbate Daga}, Giovanni and Secondo Fassino and Georg Northoff",
note = "Crown Copyright {\circledC} 2018. Published by Elsevier Masson SAS. All rights reserved.",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.eurpsy.2018.08.005",
language = "English",
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journal = "European Psychiatry",
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T1 - Neuronal variability of Resting State activity in Eating Disorders

T2 - increase and decoupling in Ventral Attention Network and relation with clinical symptoms

AU - Spalatro, Angela V.

AU - Amianto, Federico

AU - Huang, Zirui

AU - D'Agata, Federico

AU - Bergui, Mauro

AU - Abbate Daga, Giovanni

AU - Fassino, Secondo

AU - Northoff, Georg

N1 - Crown Copyright © 2018. Published by Elsevier Masson SAS. All rights reserved.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

AB - Background: Despite the great number of resting state functional connectivity studies on Eating Disorders (ED), no biomarkers could be detected yet. Therefore, we here focus on a different measure of resting state activity that is neuronal variability. The objective of this study was to investigate neuronal variability in the resting state of women with ED and to correlate possible differences with clinical and psychopathological indices. Methods: 58 women respectively 25 with Anorexia Nervosa (AN), 16 with Bulimia Nervosa (BN) and 17 matched healthy controls (CN) were enrolled for the study. All participants were tested with a battery of psychometric tests and underwent a functional Magnetic Resonance Imaging (fMRI) resting state scanning. We investigated topographical patterns of variability measured by the Standard Deviation (SD) of the Blood-Oxygen-Level-Dependent (BOLD) signal (as a measure of neuronal variability) in the resting-state and their relationship to clinical and psychopathological indices. Results: Neuronal variability was increased in both anorectic and bulimic subjects specifically in the Ventral Attention Network (VAN) compared to healthy controls. No significant differences were found in the other networks. Significant correlations were found between neuronal variability of VAN and various clinical and psychopathological indices. Conclusions: We here show increased neuronal variability of VAN in ED patients. As the VAN is relevant for switching between endogenous and exogenous stimuli, our results showing increased neuronal variability suggest unstable balance between body attention and attention to external world. These results offer new perspective on the neurobiological basis of ED. Clinical and therapeutic implication will be discussed.

KW - Eating Disorders

KW - Inhibitory control

KW - Interoceptive awareness

KW - Neuronal variability

KW - Ventral Attention Network

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KW - Brain Mapping/methods

KW - Humans

KW - Magnetic Resonance Imaging/methods

KW - Psychometrics/methods

KW - Feeding and Eating Disorders/physiopathology

KW - Ventral Thalamic Nuclei/diagnostic imaging

KW - Neuronal Plasticity/physiology

KW - Adult

KW - Female

KW - Psychopathology

KW - Attention/physiology

KW - Inhibition (Psychology)

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U2 - 10.1016/j.eurpsy.2018.08.005

DO - 10.1016/j.eurpsy.2018.08.005

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JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

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